MSC Cruises cruises from Civitavecchia (Rome)

Ranked by what people search for and where the cruise lines send the most ships.

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC World Europa

6 ports
Round trip
20 departures Nov 2027 – Apr 2028
From $779 pp
Contemporary

Messina Taormina's Ancient Greek Theatre, framed by Mount Etna
Valletta St John's Co-Cathedral & the Caravaggio masterpieces
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb

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7-night Civitavecchia (Rome) to Genoa

MSC Cruises · MSC Musica

6 ports
Round trip
25 departures Oct 2027 – Sep 2028
From $579 pp
Contemporary

Palermo Cappella Palatina & the Norman Palace — Palermo's gold-mosaic masterpiece
Ibiza Formentera Day Trip & Ses Illetes, the 'Spanish Caribbean'
Valencia Oceanografic: Walk Beneath the Sharks at Europe's Largest Aquarium

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7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Fantasia

6 ports
Round trip
25 departures Apr – Sep 2028
From $789 pp
Contemporary

Livorno (Florence/Pisa) Climb the Leaning Tower of Pisa — the Field of Miracles up close
Cannes Private Boat to Îles de Lérins: Sainte-Marguerite & Saint-Honorat
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb

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7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Magnifica

6 ports
Round trip
20 departures May – Sep 2028
From $919 pp
Contemporary

Genoa Sail straight to Portofino from the cruise dock (Golfo Paradiso ferry)
Marseille Calanques National Park Boat Cruise from the Old Port
Tarragona Private Roman Tarraco: Amphitheatre, Circus & Forum

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7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Divina

5 ports
Round trip
24 departures Apr – Sep 2028
From $1,129 pp
Contemporary

Mykonos Delos: a whole UNESCO island that is one open-air ruin
Santorini (Thira) Semi-Private Caldera Catamaran with Hot Springs & BBQ Lunch
Naples Pompeii with a Licensed Archaeologist

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7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Seaview

6 ports
Round trip
2 departures Sep – Oct 2026
From $1,006 pp
Contemporary

Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Marseille Calanques National Park Boat Cruise from the Old Port
Genoa Sail straight to Portofino from the cruise dock (Golfo Paradiso ferry)

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7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC World Asia

6 ports
Round trip
2 departures Dec 2026 – Mar 2028
From $916 pp
Contemporary

Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Marseille Calanques National Park Boat Cruise from the Old Port
Genoa Sail straight to Portofino from the cruise dock (Golfo Paradiso ferry)

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC World Asia

6 ports
Round trip
2 departures Jan – Nov 2027
From $741 pp
Contemporary

Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Marseille Calanques National Park Boat Cruise from the Old Port
Genoa Sail straight to Portofino from the cruise dock (Golfo Paradiso ferry)

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC World Asia

6 ports
Round trip
2 departures Feb – Nov 2027
From $716 pp
Contemporary

Messina Taormina's Ancient Greek Theatre, framed by Mount Etna
Valletta St John's Co-Cathedral & the Caravaggio masterpieces
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC World Asia

6 ports
Round trip
2 departures Feb 2027 – Jan 2028
From $917 pp
Contemporary

Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Marseille Calanques National Park Boat Cruise from the Old Port
Genoa Sail straight to Portofino from the cruise dock (Golfo Paradiso ferry)

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC World Asia

6 ports
Round trip
2 departures Mar 2027 – Jan 2028
From $967 pp
Contemporary

Messina Taormina's Ancient Greek Theatre, framed by Mount Etna
Valletta St John's Co-Cathedral & the Caravaggio masterpieces
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Lirica

6 ports
Round trip
2 departures Dec 2027
From $1,206 pp
Contemporary

Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Marseille Calanques National Park Boat Cruise from the Old Port
Genoa Sail straight to Portofino from the cruise dock (Golfo Paradiso ferry)

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7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Divina

5 ports
Round trip
4 departures May – Oct 2027
From $1,249 pp
Contemporary

Santorini (Thira) Semi-Private Caldera Catamaran with Hot Springs & BBQ Lunch
Mykonos Delos: a whole UNESCO island that is one open-air ruin
Naples Pompeii with a Licensed Archaeologist

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8-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC World Europa

7 ports
Round trip
2 departures Apr 2028
From $1,289 pp
Contemporary

Messina Taormina's Ancient Greek Theatre, framed by Mount Etna
Valletta St John's Co-Cathedral & the Caravaggio masterpieces
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb

See the whole trip →

5-night Civitavecchia (Rome) to Genoa

MSC Cruises · MSC World Europa

5 ports
One way
Sails Nov 9, 2026
From $599 pp
Contemporary

Messina Taormina's Ancient Greek Theatre, framed by Mount Etna
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Divina

5 ports
Round trip
3 departures May – Aug 2027
From $1,279 pp
Contemporary

Santorini (Thira) Semi-Private Caldera Catamaran with Hot Springs & BBQ Lunch
Mykonos Delos: a whole UNESCO island that is one open-air ruin
Naples Pompeii with a Licensed Archaeologist

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Divina

5 ports
Round trip
3 departures Jul – Aug 2027
From $1,359 pp
Contemporary

Mykonos Delos: a whole UNESCO island that is one open-air ruin
Santorini (Thira) Semi-Private Caldera Catamaran with Hot Springs & BBQ Lunch
Naples Pompeii with a Licensed Archaeologist

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Seaview

6 ports
Round trip
Sails Oct 18, 2026
From $1,391 pp
Contemporary

Palermo Cappella Palatina & the Norman Palace — Palermo's gold-mosaic masterpiece
Ibiza Formentera Day Trip & Ses Illetes, the 'Spanish Caribbean'
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb

See the whole trip →

7-night Mediterranean from Civitavecchia (Rome)

MSC Cruises · MSC Seaview

6 ports
Round trip
Sails Nov 1, 2026
From $825 pp
Contemporary

Palermo Cappella Palatina & the Norman Palace — Palermo's gold-mosaic masterpiece
Ibiza Formentera Day Trip & Ses Illetes, the 'Spanish Caribbean'
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb

See the whole trip →