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MSC Cruises cruises from Palermo

162 itineraries with a bookable sailing ahead, 262 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › MSC Cruises cruises from Palermo

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Ranked by what people search for and where the cruise lines send the most ships.

26-night Palermo to Miami

MSC Cruises · MSC Meraviglia

15 ports
One way
Sails Oct 16, 2026
From $2,689 pp
Contemporary

Naples Pompeii with a Licensed Archaeologist
Livorno (Florence/Pisa) Climb the Leaning Tower of Pisa — the Field of Miracles up close
Marseille Calanques National Park Boat Cruise from the Old Port

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21-night Palermo to Buenos Aires

MSC Cruises · MSC Splendida

11 ports
Repositioning
Sails Nov 12, 2026
From $4,251 pp
Contemporary

Valletta St John's Co-Cathedral & the Caravaggio masterpieces
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Gibraltar Upper Rock Nature Reserve: Private Taxi Grand Tour

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