⚓ Cruises

Mediterranean cruises from Palermo

221 itineraries with a bookable sailing ahead, 363 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › Mediterranean cruises from Palermo

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Ranked by what people search for and where the cruise lines send the most ships.

7-night Mediterranean from Palermo

Costa · Costa Pacifica

6 ports
Round trip
9 departures Nov 2027 – Mar 2028
From $771 pp
Contemporary

La Goulette Private Full-Day Carthage, Sidi Bou Said & Bardo Museum
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
8 departures Mar – May 2028
From $949 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

22-night Palermo to Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

12 ports
Repositioning
Sails Nov 12, 2027
From $8,575 pp
Contemporary

Naples Pompeii with a Licensed Archaeologist
Livorno (Florence/Pisa) Climb the Leaning Tower of Pisa — the Field of Miracles up close
Marseille Calanques National Park Boat Cruise from the Old Port

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26-night Palermo to Miami

MSC Cruises · MSC Meraviglia

15 ports
One way
Sails Oct 16, 2026
From $2,689 pp
Contemporary

Naples Pompeii with a Licensed Archaeologist
Livorno (Florence/Pisa) Climb the Leaning Tower of Pisa — the Field of Miracles up close
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

21-night Palermo to Buenos Aires

MSC Cruises · MSC Splendida

11 ports
Repositioning
Sails Nov 12, 2026
From $4,251 pp
Contemporary

Valletta St John's Co-Cathedral & the Caravaggio masterpieces
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Gibraltar Upper Rock Nature Reserve: Private Taxi Grand Tour

See the whole trip →

12-night Mediterranean from Palermo

Costa · Costa Pacifica

10 ports
Round trip
4 departures Nov 2027 – Feb 2028
From $1,207 pp
Contemporary

La Goulette Private Full-Day Carthage, Sidi Bou Said & Bardo Museum
Tangier Tangier Kasbah, Medina & American Legation Private Tour
Malaga Granada & the Alhambra: Spain's Most Famous Monument

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7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
2 departures Nov – Dec 2026
From $669 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
2 departures Dec 2026 – Feb 2027
From $669 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
2 departures Dec 2026
From $881 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
2 departures Dec 2026 – Feb 2027
From $799 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
2 departures Jan – Feb 2027
From $708 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
2 departures Jan – Feb 2027
From $648 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
2 departures Jun – Jul 2027
From $1,143 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Smeralda

6 ports
Round trip
2 departures Oct 2026
From $893 pp
Contemporary

Marseille Calanques National Park Boat Cruise from the Old Port
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Cagliari Su Nuraxi di Barumini — the only nuragic UNESCO World Heritage Site, with its mandatory archaeologist-guided climb

See the whole trip →

6-night Mediterranean from Palermo

Costa · Costa Toscana

5 ports
Round trip
Sails Dec 16, 2027
From $729 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Pacifica

5 ports
Round trip
Sails Nov 9, 2027
From $731 pp
Contemporary

Naples Pompeii with a Licensed Archaeologist
Barcelona Sagrada Familia: Gaudi's Basilica + Tower Climb
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Dec 3, 2026
From $669 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Jan 7, 2027
From $719 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Jan 14, 2027
From $719 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Feb 18, 2027
From $799 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Mar 4, 2027
From $799 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Mar 11, 2027
From $839 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Mar 18, 2027
From $1,009 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Apr 1, 2027
From $1,099 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Apr 8, 2027
From $1,099 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Apr 15, 2027
From $1,099 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Apr 22, 2027
From $1,099 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Apr 29, 2027
From $1,139 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails May 6, 2027
From $1,139 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Sep 30, 2027
From $1,079 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Oct 7, 2027
From $1,079 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Oct 14, 2027
From $1,079 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Oct 21, 2027
From $1,059 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Oct 28, 2027
From $1,029 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Nov 4, 2027
From $989 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Nov 11, 2027
From $959 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails Nov 18, 2027
From $939 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Smeralda

6 ports
Round trip
Sails Oct 1, 2026
From $1,073 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails May 13, 2027
From $1,143 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

7-night Mediterranean from Palermo

Costa · Costa Toscana

6 ports
Round trip
Sails May 20, 2027
From $1,143 pp
Contemporary

Civitavecchia (Rome) Vatican, Sistine Chapel & Colosseum in One Day (skip-the-line, private)
Savona (Genoa) Portofino & San Fruttuoso Abbey by the local ferry
Marseille Calanques National Park Boat Cruise from the Old Port

See the whole trip →

Prefer a calendar? →The ports themselves →