⚓ Cruises

South America cruises from Rio de Janeiro

43 itineraries with a bookable sailing ahead, 67 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › South America cruises from Rio de Janeiro

Cruise line

MSC Cruises32 Regent1 Azamara1 Cunard1 Costa8

Most popular first

Ranked by what people search for and where the cruise lines send the most ships.

Buzios

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

6 ports
Round trip
13 departures Jan 2027 – Feb 2028
From $701 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
7 departures Dec 2027 – Mar 2028
From $884 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Buzios

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
4 departures Jan – Feb 2028
From $1,137 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Buzios

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
2 departures Jan 2028
From $1,247 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Buenos Aires

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
2 departures Dec 2026
From $1,676 pp
Contemporary

Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Santos (Sao Paulo)

1-night Rio de Janeiro to Santos (Sao Paulo)

MSC Cruises · MSC Divina

2 ports
One way
Sails Nov 15, 2026
From $83 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Santos (Sao Paulo)

1-night Rio de Janeiro to Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

2 ports
One way
Sails Dec 1, 2026
From $70 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Buzios

6-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

5 ports
Round trip
2 departures Dec 2027 – Jan 2028
From $809 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

Montevideo

4-night Rio de Janeiro to Buenos Aires

MSC Cruises · MSC Splendida

3 ports
One way
Sails Nov 29, 2026
From $1,589 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Buzios

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 17, 2027
From $1,501 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Buzios

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 26, 2027
From $1,720 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Buzios

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Feb 4, 2027
From $1,766 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Buzios

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 8, 2027
From $1,796 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Dec 6, 2026
From $1,451 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Dec 14, 2026
From $1,261 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Feb 22, 2027
From $1,551 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 2, 2027
From $1,331 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 10, 2027
From $1,336 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 18, 2027
From $1,336 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 26, 2027
From $1,691 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilhabela

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 11, 2028
From $884 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Buzios

6-night Rio de Janeiro to Santos (Sao Paulo)

MSC Cruises · MSC Musica

6 ports
One way
Sails Mar 9, 2027
From $1,049 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

See the whole trip →

Ilhabela

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Feb 13, 2027
From $1,473 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Copacabana Beach

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Dec 31, 2026
From $2,459 pp
Contemporary

Copacabana Beach Christ the Redeemer: Private Summit Access at Dawn
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Ilha Grande

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

6 ports
Round trip
Sails Dec 22, 2026
From $976 pp
Contemporary

Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

See the whole trip →

Buzios

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

6 ports
Round trip
Sails Jan 19, 2027
From $946 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

See the whole trip →

Ilha Grande

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

6 ports
Round trip
Sails Jan 26, 2027
From $896 pp
Contemporary

Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

See the whole trip →

Buzios

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

6 ports
Round trip
Sails Feb 2, 2027
From $896 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

See the whole trip →

Buzios

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

6 ports
Round trip
Sails Feb 9, 2027
From $1,046 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

See the whole trip →

Buzios

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

6 ports
Round trip
Sails Feb 16, 2027
From $829 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

See the whole trip →

Ilha Grande

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

7 ports
Round trip
Sails Dec 29, 2026
From $1,397 pp
Contemporary

Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Copacabana Beach Christ the Redeemer: Private Summit Access at Dawn

See the whole trip →

Ilha Grande

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

7 ports
Round trip
Sails Dec 29, 2027
From $1,641 pp
Contemporary

Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Copacabana Beach Christ the Redeemer: Private Summit Access at Dawn

See the whole trip →

Buzios

11-night Rio de Janeiro to Buenos Aires

Regent · Seven Seas Mariner

10 ports
One way
Sails Jan 22, 2027
From $13,199 pp
Luxury

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

Paraty

10-night Rio de Janeiro to Buenos Aires

Azamara · Azamara Journey

6 ports
One way
Sails Feb 7, 2027
From $3,000 pp
Luxury

Paraty Private Schooner Charter: Paraty Bay Islands & Hidden Beaches
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Santos (Sao Paulo)

20-night Rio de Janeiro to San Antonio

Cunard · Queen Anne

12 ports
One way
Sails Feb 8, 2027
From $4,109 pp
Premium

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Buenos Aires

3-night Rio de Janeiro to Buenos Aires

Costa · Costa Serena

2 ports
One way
Sails Mar 13, 2027
From $613 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Ilhabela

9-night South America from Rio de Janeiro

Costa · Costa Serena

5 ports
Round trip
Sails Jan 10, 2027
From $1,781 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Buenos Aires

8-night South America from Rio de Janeiro

Costa · Costa Serena

5 ports
Round trip
Sails Jan 19, 2027
From $1,691 pp
Contemporary

Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Ilhabela

9-night South America from Rio de Janeiro

Costa · Costa Serena

5 ports
Round trip
Sails Mar 4, 2027
From $1,575 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Iiha Grande(Rio De Janeiro)

9-night South America from Rio de Janeiro

Costa · Costa Serena

6 ports
Round trip
Sails Jan 27, 2027
From $1,721 pp
Contemporary

Iiha Grande(Rio De Janeiro) Lopes Mendes Beach: Private Hike Through Atlantic Rainforest
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

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