⚓ Cruises

Royal Caribbean Mexico cruises from San Diego

17 itineraries with a bookable sailing ahead, 47 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › Royal Caribbean Mexico cruises from San Diego

Most popular first

Ranked by what people search for and where the cruise lines send the most ships.

Ensenada

3-night Mexico from San Diego

Royal Caribbean · Serenade of the Seas

  • 2 ports
  • Round trip
  • 14 departures Oct 2026 – Apr 2027
  • From $219 pp
  • Contemporary
  • San Diego San Diego Zoo: Wildlife Showcase at the World's Greatest Zoo
  • Ensenada Valle de Guadalupe wine country: boutique winery tastings (Decantos, Monte Xanic, Vena Cava) with a private driver
See the whole trip →
Avalon

4-night Mexico from San Diego

Royal Caribbean · Serenade of the Seas

  • 3 ports
  • Round trip
  • 5 departures Oct 2026 – Mar 2027
  • From $259 pp
  • Contemporary
  • San Diego San Diego Zoo: Wildlife Showcase at the World's Greatest Zoo
  • Avalon Private Golf Cart Tour of Avalon with Expert Local Guide
  • Ensenada Valle de Guadalupe wine country: boutique winery tastings (Decantos, Monte Xanic, Vena Cava) with a private driver
See the whole trip →
Avalon

4-night Mexico from San Diego

Royal Caribbean · Serenade of the Seas

  • 3 ports
  • Round trip
  • 5 departures Jan – Mar 2027
  • From $289 pp
  • Contemporary
  • San Diego San Diego Zoo: Wildlife Showcase at the World's Greatest Zoo
  • Avalon Private Golf Cart Tour of Avalon with Expert Local Guide
  • Ensenada Valle de Guadalupe wine country: boutique winery tastings (Decantos, Monte Xanic, Vena Cava) with a private driver
See the whole trip →
Avalon

4-night Mexico from San Diego

Royal Caribbean · Serenade of the Seas

  • 3 ports
  • Round trip
  • 4 departures Jan – Apr 2027
  • From $277 pp
  • Contemporary
  • San Diego San Diego Zoo: Wildlife Showcase at the World's Greatest Zoo
  • Avalon Private Golf Cart Tour of Avalon with Expert Local Guide
  • Ensenada Valle de Guadalupe wine country: boutique winery tastings (Decantos, Monte Xanic, Vena Cava) with a private driver
See the whole trip →
Ensenada

3-night Mexico from San Diego

Royal Caribbean · Serenade of the Seas

  • 2 ports
  • Round trip
  • 2 departures Mar – Apr 2027
  • From $337 pp
  • Contemporary
  • San Diego San Diego Zoo: Wildlife Showcase at the World's Greatest Zoo
  • Ensenada Valle de Guadalupe wine country: boutique winery tastings (Decantos, Monte Xanic, Vena Cava) with a private driver
See the whole trip →
Ensenada

7-night Mexico from San Diego

Royal Caribbean · Serenade of the Seas

  • 4 ports
  • Round trip
  • 2 departures Nov 2026 – Apr 2027
  • From $369 pp
  • Contemporary
  • Ensenada Valle de Guadalupe wine country: boutique winery tastings (Decantos, Monte Xanic, Vena Cava) with a private driver
  • Cabo San Lucas El Arco & Lover's Beach: Private Yacht at Land's End
  • La Paz Snorkel with Whale Sharks near La Paz
See the whole trip →
Avalon

7-night Mexico from San Diego

Royal Caribbean · Serenade of the Seas

  • 4 ports
  • Round trip
  • Sails Dec 13, 2026
  • From $438 pp
  • Contemporary
  • Avalon Private Golf Cart Tour of Avalon with Expert Local Guide
  • Ensenada Valle de Guadalupe wine country: boutique winery tastings (Decantos, Monte Xanic, Vena Cava) with a private driver
  • Cabo San Lucas El Arco & Lover's Beach: Private Yacht at Land's End
See the whole trip →
Avalon

4-night Mexico from San Diego

Royal Caribbean · Serenade of the Seas

  • 3 ports
  • Round trip
  • Sails Mar 7, 2027
  • From $327 pp
  • Contemporary
  • San Diego San Diego Zoo: Wildlife Showcase at the World's Greatest Zoo
  • Avalon Private Golf Cart Tour of Avalon with Expert Local Guide
  • Ensenada Valle de Guadalupe wine country: boutique winery tastings (Decantos, Monte Xanic, Vena Cava) with a private driver
See the whole trip →
Prefer a calendar? →The ports themselves →