⚓ Cruises

South America cruises from Santos (Sao Paulo)

62 itineraries with a bookable sailing ahead, 222 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › South America cruises from Santos (Sao Paulo)

Cruise line

MSC Cruises48 Costa14

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Ranked by what people search for and where the cruise lines send the most ships.

Ilha Grande

5-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

4 ports
Round trip
Sails Dec 21, 2026
From $949 pp
Contemporary

Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

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Ilhabela

7-night Santos (Sao Paulo) to Itajai

MSC Cruises · MSC Musica

6 ports
One way
Sails Dec 20, 2027
From $1,099 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

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Ilha Grande

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

3 ports
Round trip
Sails Nov 16, 2026
From $486 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

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Buzios

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

3 ports
Round trip
Sails Dec 16, 2027
From $415 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Porto Belo (Santa Catarina) Ilha de Porto Belo: Private Ecological Island Boat Tour

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Angra Dos Reis

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

3 ports
Round trip
Sails Dec 18, 2026
From $419 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Angra Dos Reis Private Speedboat to Lopes Mendes & Lagoa Azul
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

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Buzios

8-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

5 ports
Round trip
Sails Dec 18, 2027
From $1,219 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Maceio Praia do Gunga: Private Jangada & Secluded Beach Day

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Buzios

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

5 ports
Round trip
Sails Dec 26, 2026
From $1,849 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Copacabana Beach Christ the Redeemer: Private Summit Access at Dawn

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Buzios

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

5 ports
Round trip
Sails Dec 26, 2027
From $1,549 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Copacabana Beach Christ the Redeemer: Private Summit Access at Dawn

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
6 departures Dec 2026 – Feb 2027
From $1,125 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

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Montevideo

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
6 departures Jan – Mar 2027
From $1,075 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Santos (Sao Paulo)

3-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

2 ports
Round trip
6 departures Nov – Dec 2026
From $560 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

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Ilhabela

4-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

3 ports
Round trip
6 departures Nov 2026 – Apr 2027
From $734 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
4 departures Dec 2026 – Feb 2027
From $1,125 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
4 departures Feb – Mar 2027
From $1,103 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
3 departures Dec 2026 – Feb 2027
From $1,133 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
3 departures Jan – Mar 2027
From $1,095 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Santos (Sao Paulo)

3-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

2 ports
Round trip
3 departures Nov – Dec 2026
From $920 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

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Ilhabela

4-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

3 ports
Round trip
3 departures Dec 2026 – Mar 2027
From $714 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
2 departures Jan – Mar 2027
From $1,543 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
Sails Dec 27, 2026
From $2,013 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
Sails Jan 31, 2027
From $1,593 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Buenos Aires

7-night South America from Santos (Sao Paulo)

Costa · Costa Diadema

4 ports
Round trip
Sails Feb 14, 2027
From $1,573 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

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