⚓ Cruises

South America cruises

260 itineraries with a bookable sailing ahead, 555 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › South America cruises

Sailing from

Buenos Aires63 Santos (Sao Paulo)62 Rio de Janeiro43 Itajai22 Montevideo16 Camboriú12 Paranagua10 Bahia de Salvador9 Valparaiso (Santiago)7 Maceio4 San Antonio3 Buenos Aires2 Lima2 Callao (Lima)2

Cruise line

MSC Cruises153 Princess4 Celebrity9 Viking Ocean12 Oceania5 Holland America3 Silversea3 Regent3 Azamara2 Cunard1 Costa63 Avalon2

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Ranked by what people search for and where the cruise lines send the most ships.

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

3 ports
Round trip
Sails Nov 26, 2026
From $526 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

3 ports
Round trip
Sails Mar 4, 2027
From $559 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

3 ports
Round trip
Sails Mar 22, 2027
From $496 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

3 ports
Round trip
Sails Dec 9, 2027
From $415 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail

See the whole trip →

9-night South America from Buenos Aires

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 14, 2027
From $2,220 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 17, 2027
From $1,501 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

9-night South America from Buenos Aires

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 23, 2027
From $2,220 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 26, 2027
From $1,720 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

9-night South America from Buenos Aires

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Feb 1, 2027
From $2,007 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Feb 4, 2027
From $1,766 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

9-night South America from Buenos Aires

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 5, 2027
From $2,242 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
Sails Jan 8, 2027
From $1,796 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

4-night Bahia de Salvador to Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

3 ports
One way
Sails Mar 30, 2027
From $546 pp
Contemporary

Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Maceio Praia do Gunga: Private Jangada & Secluded Beach Day
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

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6-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

4 ports
Round trip
Sails Jan 2, 2028
From $889 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail

See the whole trip →

6-night South America from Bahia de Salvador

MSC Cruises · MSC Virtuosa

4 ports
Round trip
Sails Jan 5, 2028
From $939 pp
Contemporary

Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

5-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

4 ports
Round trip
Sails Dec 21, 2026
From $949 pp
Contemporary

Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Dec 6, 2026
From $1,451 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Dec 14, 2026
From $1,261 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

8-night South America from Buenos Aires

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Feb 19, 2027
From $1,862 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Feb 22, 2027
From $1,551 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

8-night South America from Buenos Aires

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Feb 27, 2027
From $1,951 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 2, 2027
From $1,331 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 10, 2027
From $1,336 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

8-night South America from Buenos Aires

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 15, 2027
From $1,862 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 18, 2027
From $1,336 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

8-night South America from Buenos Aires

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 23, 2027
From $1,750 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 26, 2027
From $1,691 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

8-night South America from Buenos Aires

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 8, 2028
From $929 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
Sails Mar 11, 2028
From $884 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

7-night Santos (Sao Paulo) to Itajai

MSC Cruises · MSC Musica

6 ports
One way
Sails Dec 20, 2027
From $1,099 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

3 ports
Round trip
Sails Nov 16, 2026
From $486 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

3 ports
Round trip
Sails Dec 16, 2027
From $415 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Porto Belo (Santa Catarina) Ilha de Porto Belo: Private Ecological Island Boat Tour

See the whole trip →