South America cruises

Ranked by what people search for and where the cruise lines send the most ships.

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

4 ports
Round trip
27 departures Dec 2026 – Mar 2028
From $864 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Maceio Praia do Gunga: Private Jangada & Secluded Beach Day

See the whole trip →

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

2 ports
Round trip
18 departures Dec 2026 – Mar 2028
From $409 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

2 ports
Round trip
14 departures Nov 2026 – Dec 2027
From $353 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

4 ports
Round trip
14 departures Dec 2026 – Mar 2027
From $629 pp
Contemporary

Maceio Praia do Gunga: Private Jangada & Secluded Beach Day
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

4 ports
Round trip
13 departures Dec 2027 – Mar 2028
From $829 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Maceio Praia do Gunga: Private Jangada & Secluded Beach Day

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Meraviglia

4 ports
Round trip
11 departures Nov 2027 – Mar 2028
From $829 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

7-night South America from Buenos Aires

MSC Cruises · MSC Meraviglia

4 ports
Round trip
11 departures Dec 2027 – Mar 2028
From $928 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

7-night South America from Maceio

MSC Cruises · MSC Virtuosa

4 ports
Round trip
12 departures Dec 2027 – Mar 2028
From $864 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide

See the whole trip →

7-night South America from Camboriú

MSC Cruises · MSC Meraviglia

4 ports
Round trip
10 departures Nov 2027 – Mar 2028
From $889 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

7-night South America from Paranagua

MSC Cruises · MSC Musica

6 ports
Round trip
13 departures Jan 2027 – Feb 2028
From $701 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

7-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

6 ports
Round trip
13 departures Jan 2027 – Feb 2028
From $701 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba

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7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

4 ports
Round trip
9 departures Dec 2026 – Mar 2027
From $1,016 pp
Contemporary

Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Maceio Praia do Gunga: Private Jangada & Secluded Beach Day
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

7-night South America from Maceio

MSC Cruises · MSC Virtuosa

4 ports
Round trip
7 departures Jan – Mar 2027
From $1,026 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide

See the whole trip →

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Meraviglia

2 ports
Round trip
5 departures Nov 2027 – Apr 2028
From $393 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

8-night South America from Buenos Aires

MSC Cruises · MSC Splendida

5 ports
Round trip
7 departures Dec 2027 – Mar 2028
From $899 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

8-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
7 departures Dec 2027 – Mar 2028
From $884 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

3 ports
Round trip
6 departures Nov 2026 – Mar 2028
From $479 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

7-night South America from Itajai

MSC Cruises · MSC Musica

6 ports
Round trip
8 departures Jan – Feb 2028
From $771 pp
Contemporary

Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

9-night South America from Buenos Aires

MSC Cruises · MSC Splendida

6 ports
Round trip
4 departures Jan – Feb 2028
From $1,190 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
4 departures Jan – Feb 2028
From $1,137 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
3 departures Dec 2026 – Jan 2027
From $1,299 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
3 departures Dec 2026 – Feb 2027
From $1,369 pp
Contemporary

Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
3 departures Dec 2026 – Feb 2027
From $1,319 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

7-night South America from Camboriú

MSC Cruises · MSC Seaview

4 ports
Round trip
3 departures Jan – Feb 2027
From $1,369 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Musica

3 ports
Round trip
3 departures Dec 2026 – Mar 2027
From $485 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Meraviglia

3 ports
Round trip
3 departures Mar – Apr 2028
From $465 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail

See the whole trip →

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

2 ports
Round trip
2 departures Feb 2027
From $569 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

8-night South America from Buenos Aires

MSC Cruises · MSC Splendida

5 ports
Round trip
3 departures Dec 2026 – Mar 2027
From $1,716 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

7-night South America from Buenos Aires

MSC Cruises · MSC Meraviglia

4 ports
Round trip
2 departures Jan – Mar 2028
From $968 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Meraviglia

4 ports
Round trip
2 departures Jan – Mar 2028
From $869 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

7-night South America from Camboriú

MSC Cruises · MSC Meraviglia

4 ports
Round trip
2 departures Jan – Mar 2028
From $929 pp
Contemporary

Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

7-night South America from Buenos Aires

MSC Cruises · MSC Seaview

4 ports
Round trip
2 departures Dec 2026 – Jan 2027
From $1,337 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
2 departures Dec 2026 – Feb 2027
From $949 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
2 departures Jan – Mar 2027
From $947 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

7-night South America from Camboriú

MSC Cruises · MSC Seaview

4 ports
Round trip
2 departures Jan – Feb 2027
From $1,337 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

7-night South America from Buenos Aires

MSC Cruises · MSC Seaview

4 ports
Round trip
2 departures Jan – Feb 2027
From $1,337 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

7-night South America from Camboriú

MSC Cruises · MSC Seaview

4 ports
Round trip
2 departures Feb 2027
From $1,299 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

3-night Maceio to Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

2 ports
One way
2 departures Dec 2026 – Mar 2027
From $374 pp
Contemporary

Maceio Praia do Gunga: Private Jangada & Secluded Beach Day
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

3 ports
Round trip
2 departures Feb 2027
From $559 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail

See the whole trip →

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

3 ports
Round trip
2 departures Feb 2027
From $559 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilha Grande Lopes Mendes Beach: Private Speedboat & Jungle Trail

See the whole trip →

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