Bucket-List Cruise Adventures

Pick your sailing — we plan the whole adventure

Bucket-list adventures at every port — where to fly in, and what to do the day(s) before and after.

When are you free? — only cruises that fit entirely inside your dates
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Where to? tap as many as you like Caribbean Mediterranean Alaska Bahamas Mexico Northern Europe Hawaii Bermuda Europe Asia Australia & South Pacific Panama Canal South America North America Pacific Middle East Africa
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Luxury Azamara Oceania Regent Seabourn Viking Ocean River AmaWaterways Avalon Viking River Premium Celebrity Cunard Disney Holland America Princess Virgin Voyages Contemporary Carnival Costa MSC Cruises Norwegian Royal Caribbean
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Filtering Regent ×Visits Panama City ×13+ nights × Clear all
Showing 6 of 6 sailings
Regent · Seven Seas SplendorOne-way
Mediterranean 14 nights Jan 12 – Jan 26, 2027 from Miami, Florida to Panama City, Panama
Miami, Florida · Willis Island · … · Panama City, Panama15 ports
Miami, Florida · Willis Island · Cozumel, Mexico · Costa Maya, Mexico · Harvest Caye, Belize · Roatan, Honduras · Willis Island · Georgetown, Grand Cayman, Cayman Islands · Ocho Rios, Jamaica · Willis Island · Puerto Limon, Costa Rica · Willis Island · Cartagena, Spain · Panama Canal, Panama · Panama City, Panama
★ Bucket-list Star Island & Millionaire's Row Skyline Cruise on…Zodiac Circumnavigation of Willis IslandEl Cielo + Palancar + Columbia 3-Stop SnorkelChacchoben Mayan Ruins +7 more
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from $14,099
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Regent · Seven Seas SplendorOne-way
Pacific 28 nights Jan 26 – Feb 23, 2027 from Panama City, Panama to Papeete, Tahiti, French Polynesia
Panama City, Panama · Willis Island · … · Papeete, Tahiti, French Polynesia19 ports
Panama City, Panama · Willis Island · Puntarenas, Costa Rica · Willis Island · Acajutla, El Salvador · Puerto Quetzal, Guatemala · Willis Island · Puerto Vallarta, Mexico · Cabo San Lucas, Mexico · Willis Island · Los Angeles, California · Willis Island · Honolulu, Oahu, Hawaii · Kahului, Maui, Hawaii · Hilo, Hawaii · Willis Island · Bora Bora, French Polynesia · Moorea, French Polynesia · Papeete, Tahiti, French Polynesia
★ Bucket-list Panama Canal Miraflores LocksZodiac Circumnavigation of Willis IslandMonteverde Cloud ForestTazumal Mayan Ruins +10 more
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from $17,710
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Regent · Seven Seas GrandeurOne-way
Mediterranean 14 nights Feb 23 – Mar 9, 2027 from Miami, Florida to Panama City, Panama
Miami, Florida · Willis Island · … · Panama City, Panama15 ports
Miami, Florida · Willis Island · Costa Maya, Mexico · Harvest Caye, Belize · Roatan, Honduras · Willis Island · Georgetown, Grand Cayman, Cayman Islands · Ocho Rios, Jamaica · Willis Island · Puerto Limon, Costa Rica · Willis Island · Cartagena, Spain · Colon, Panama · Panama Canal, Panama · Panama City, Panama
★ Bucket-list Star Island & Millionaire's Row Skyline Cruise on…Zodiac Circumnavigation of Willis IslandChacchoben Mayan RuinsLamanai Mayan Ruins +7 more
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from $9,299
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Regent · Seven Seas GrandeurRound-trip
Caribbean 22 nights Mar 9 – Mar 31, 2027 from Panama City, Panama
Panama City, Panama · Panama Canal, Panama · … · Panama City, Panama17 ports
Panama City, Panama · Panama Canal, Panama · Willis Island · Oranjestad, Sint Eustatius · Willis Island · Port of Spain, Trinidad · Willis Island · Manaus, Brazil · Boca da Valeria, Brazil · Alter do Chao, Brazil · Willis Island · St. Georges, Grenada, West Indies · Willis Island · Willemstad, Curacao · Willis Island · Panama Canal, Panama · Panama City, Panama
★ Bucket-list Panama Canal Miraflores LocksPanama Canal Full TransitZodiac Circumnavigation of Willis IslandThe Natural Pool +2 more
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from $20,949
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Regent · Seven Seas MarinerOne-way
Panama Canal 16 nights Mar 10 – Mar 26, 2027 from Lima, Peru to Miami, Florida
Lima, Peru · Salaverry (Trujillo), Peru · … · Miami, Florida16 ports
Lima, Peru · Salaverry (Trujillo), Peru · Willis Island · Guayaquil (Quito), Ecuador · Manta (Quito), Ecuador · Willis Island · Golfito, Costa Rica · Panama City, Panama · Panama Canal, Panama · Puerto Limon, Costa Rica · Willis Island · Roatan, Honduras · Harvest Caye, Belize · Costa Maya, Mexico · Willis Island · Miami, Florida
★ Bucket-list Zodiac Circumnavigation of Willis IslandPanama Canal Miraflores LocksPanama Canal Full TransitHold a Sloth at Daniel Johnson's Monkey & Sloth Ha… +3 more
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from $12,099
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Regent · Seven Seas GrandeurOne-way
Mediterranean 14 nights Mar 31 – Apr 14, 2027 from Panama City, Panama to Miami, Florida
Panama City, Panama · Kiel Canal, Germany · … · Miami, Florida14 ports
Panama City, Panama · Kiel Canal, Germany · Cartagena, Spain · Santa Marta, Colombia · Oranjestad, Sint Eustatius · Willemstad, Curacao · Kralendijk, Bonaire, Dutch Antilles · Willis Island · St. Georges, Grenada, West Indies · Castries, St. Lucia · Gustavia, St. Barts · Tortola, B.V.I. · Willis Island · Miami, Florida
★ Bucket-list Panama Canal Miraflores LocksPrivate Expert Walking Tour of KielThe Roman Theatre of Cartagena with the Rafael Mon…The Natural Pool +8 more
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from $8,699
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Itineraries from the Cruisebound catalog + our enrichment; schedules cross-checked against official port authorities. Booking via Cruisebound and CruiseDirect — we may earn a commission, at no extra cost to you.

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MSC Cruises Royal Caribbean Carnival Viking River Costa Norwegian AmaWaterways Princess Celebrity Viking Ocean Avalon Disney Holland America Oceania Virgin Voyages Regent Cunard Seabourn Azamara