Bucket-List Cruise Adventure

22-Night Caribbean & Panama Canal Cruise Adventure

Regent · Seven Seas Grandeur · round-trip from Panama City

$23,449 per person · next sails Mar 9, 2027 Book this cruise@ Cruisebound · same fare
Get there

Fly into Panama City (PTY)

Your gateway to the voyage. Arrive a day or two early — the best of the trip starts before you board.

Round-trip into PTY · $1,472 for two est.
Before you sail

Bucket-list days near Panama City

Fly in at least a day early — every seasoned cruiser does, so a delay never costs you the ship. Here’s what’s worth that day, within reach of your port — not just the city you fly into.

0 mi from Panama City

Panama Canal Tour

0 mi from Panama City

San Blas Islands Day Trip

Your voyage · 22 nights, day by day

Day by day — the unforgettable thing at every port

Your whole sailing in order: the day you board, every port it calls — each with the single bucket-list experience there and the operator who runs it — any days at sea, and the day you step off.

Day 1
Panama City Embark
Board in the afternoon — fly in at least a day early (your day ashore here is just above).
Day 2
Panama Canalport guide →
★ Panama Canal Full Transit — how to make it yours →
Day 3
Willis Islandport guide →
★ Zodiac Circumnavigation of Willis Island — how to make it yours →
Day 4
Oranjestadport guide →
Coastal Horseback Ride to Wariruri Beach + Natural… · $398 for two with The Gold Mine Ranch (official)how to make it yours →
Day 5
Willis Islandport guide →
★ Zodiac Circumnavigation of Willis Island — how to make it yours →
Day 6
Port of Spainport guide →
Gasparee Caves & Gulf of Paria Private Boat Charter · $110 for two with Prime Charters Trinidadhow to make it yours → ·
Days 7–10
Willis Islandport guide →
★ Zodiac Circumnavigation of Willis Island — how to make it yours →
Days 11–12
Meeting of the Waters · $300 for two with Amazon Private Tourshow to make it yours → ·
Day 13
Boca da Valeriaport guide →
Private Motorized Canoe Deep into the Amazon Tribu… · $240 for two with Tours by Locals – Amazon River Private Guideshow to make it yours → ·
Day 14
Alter do Chaoport guide →
Jari Canal Private Tour · $206 for two with Selvagem Tours (Karlos)how to make it yours → ·
Days 15–17
Willis Islandport guide →
★ Zodiac Circumnavigation of Willis Island — how to make it yours →
Day 18
St. Georgesport guide →
Grenada Private Taxi Tour · $160 for two with Grand Tours Grenada (Call the Boss Taxi)how to make it yours → ·
Day 19
Willis Islandport guide →
★ Zodiac Circumnavigation of Willis Island — how to make it yours →
Day 20
Willemstadport guide →
Private Full-Day Curaçao Island Tour with Local Ex… · $438 for two with Dundu Tours (certified local guide, Willemstad)how to make it yours → ·
Day 21
Willis Islandport guide →
★ Zodiac Circumnavigation of Willis Island — how to make it yours →
Day 22
Panama Canalport guide →
★ Panama Canal Full Transit — how to make it yours →
Day 23
Panama City Disembark
Back where you started — disembark in the morning.
Before you sail

Make it longer — by land from Panama City

The ship is the spine, not the whole trip. These are full land adventures within reach of your port.

11 mi from Panama City · fly PTY

Balboa & Beyond: Panama's Wild, Cultured Other Side

Rainforest Meets Ruin Culture

See the whole plan →
11 mi from Panama City · fly PTY

San Blas Islands: Molas, Medicine Men & Midnight Snorkels

Indigenous Culture Meets Caribbean Wild

See the whole plan →
291 mi from Panama City · fly CTG

Cartagena's Caribbean Edge: Mud Volcanoes, Maroon Villages & Market Chaos

Caribbean Culture & Coast

See the whole plan →
After you disembark

Make it longer — by land from Panama City

The ship is the spine, not the whole trip. These are full land adventures within reach of your port.

11 mi from Panama City · fly PTY

Balboa & Beyond: Panama's Wild, Cultured Other Side

Rainforest Meets Ruin Culture

See the whole plan →
11 mi from Panama City · fly PTY

San Blas Islands: Molas, Medicine Men & Midnight Snorkels

Indigenous Culture Meets Caribbean Wild

See the whole plan →
291 mi from Panama City · fly CTG

Cartagena's Caribbean Edge: Mud Volcanoes, Maroon Villages & Market Chaos

Caribbean Culture & Coast

See the whole plan →
Home

Fly home from Panama City (PTY)

What this adventure runs estimated · for two
Your hotel
Flights round-trip into PTY · 2 travelers $1,472 est.
Hotel before you sail1 night · Panama City · Luxury~$180
Cruise fare22 nights · Regent · 2 guests$46,898
Shore excursions7 bucket-list things, booked direct · for 2 · swap any at its port above ↑~$1,852
Transfersairport ↔ ship, private car~$180
Trip total$50,582
Flights are estimated from our best gateways (refine from your own airport above); the cruise fare is this sailing’s lead-in price for two; the hotel scales with the style you pick above; shore excursions are real book-direct operator prices, added as each port is curated; transfers are an estimate. We always build in at least one night ashore before you sail.
🚢 Book this cruise · $23,449 pp

Book your trip to Panama City

We may earn a commission when you book through these links, at no extra cost to you. Prices and availability are set by each partner.

Choose your line & sailing date

Every cruise line that calls at Panama City — round-trip from here or stopping by — pick the one that’s you, then your date.

Contemporary
Premium
Luxury
Book this cruise — $23,449 pp →

Same fare as booking direct. We earn a small commission — it costs you nothing.

★ Why Fantasize

We tell you the cruise to take — and the excursions to book.

Most cruise sites hand you a search box and leave you to it. We’re the concierge: the verdict, the plan, the trip of your life — at the exact same fare.

11,000 sailings to sift throughOne cruise, chosen for you
Search a catalog of excursions yourselfWe tell you the exact excursions to book
“Do your homework” on every portA free port-by-port plan, in your inbox
Booking fees and a pushy upsell callNo fees, no pressure — the same fare
Find your bucket-list cruise →

⚓ Your bucket-list concierge

Want this whole adventure in your inbox?

We'll email you this exact plan — where to fly in, the days before and after, the single most extraordinary thing to do at every port, and what it all runs.

We send the plan to your account’s own address — never to one typed into a box. Free, and Google works.

← Browse every bucket-list cruise