⚓ Cruises

Europe cruises from Frankfurt am Main

13 itineraries with a bookable sailing ahead, 15 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › Europe cruises from Frankfurt am Main

Cruise line

Avalon12 AmaWaterways1

Most popular first

Ranked by what people search for and where the cruise lines send the most ships.

Mainz

7-night Frankfurt am Main to Basel

Avalon · Avalon View

6 ports
One way
2 departures Nov – Dec 2027
From $4,701 pp
River

Mainz Private Expert Walking Tour of Mainz's Historic Old Town
Cologne Climb the Cathedral South Tower — 533 steps to the Rhine panorama
Strasbourg Climb Strasbourg Cathedral's Spire Platform + Catch the Astronomical Clock

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Strasbourg

4-night Frankfurt am Main to Basel

Avalon · Avalon Imagery II

4 ports
One way
Sails Dec 6, 2026
From $2,781 pp
River

Strasbourg Climb Strasbourg Cathedral's Spire Platform + Catch the Astronomical Clock
Breisach am Rhein Colmar & the Alsace Wine Route — Eguisheim, Riquewihr, Kaysersberg by private driver-guide
Basel Float the Rhine through the medieval Old Town with a Wickelfisch dry-bag

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Strasbourg

4-night Frankfurt am Main to Basel

Avalon · Avalon Tranquility II

4 ports
One way
Sails Dec 16, 2026
From $2,281 pp
River

Strasbourg Climb Strasbourg Cathedral's Spire Platform + Catch the Astronomical Clock
Breisach am Rhein Colmar & the Alsace Wine Route — Eguisheim, Riquewihr, Kaysersberg by private driver-guide
Basel Float the Rhine through the medieval Old Town with a Wickelfisch dry-bag

See the whole trip →

Strasbourg

4-night Frankfurt am Main to Basel

Avalon · Avalon Illumination

4 ports
One way
Sails Dec 18, 2026
From $2,406 pp
River

Strasbourg Climb Strasbourg Cathedral's Spire Platform + Catch the Astronomical Clock
Breisach am Rhein Colmar & the Alsace Wine Route — Eguisheim, Riquewihr, Kaysersberg by private driver-guide
Basel Float the Rhine through the medieval Old Town with a Wickelfisch dry-bag

See the whole trip →

Strasbourg

4-night Frankfurt am Main to Basel

Avalon · Avalon Vista

4 ports
One way
Sails Dec 14, 2027
From $3,093 pp
River

Strasbourg Climb Strasbourg Cathedral's Spire Platform + Catch the Astronomical Clock
Breisach am Rhein Colmar & the Alsace Wine Route — Eguisheim, Riquewihr, Kaysersberg by private driver-guide
Basel Float the Rhine through the medieval Old Town with a Wickelfisch dry-bag

See the whole trip →

Mainz

7-night Frankfurt am Main to Basel

Avalon · Avalon Envision

6 ports
One way
Sails Dec 7, 2027
From $4,801 pp
River

Mainz Private Expert Walking Tour of Mainz's Historic Old Town
Cologne Climb the Cathedral South Tower — 533 steps to the Rhine panorama
Strasbourg Climb Strasbourg Cathedral's Spire Platform + Catch the Astronomical Clock

See the whole trip →

Mainz

7-night Frankfurt am Main to Nuremberg

AmaWaterways · AmaCerto

8 ports
One way
2 departures Dec 2027
From $3,829 pp
River

Mainz Private Expert Walking Tour of Mainz's Historic Old Town
Rudesheim am Rhein Seilbahn Rüdesheim: gondola over the vineyards to the Niederwald Monument
Koblenz Glass-Floor Cable Car to Ehrenbreitstein Fortress

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Wurzburg

11-night Frankfurt am Main to Vienna

Avalon · Avalon Expression

8 ports
One way
Sails Nov 29, 2027
From $7,519 pp
River

Wurzburg Würzburg Residenz: Private Guided Palace & Fresco Masterpiece
Bamberg Private Walking Tour: Bamberg UNESCO Old Town Unveiled
Nuremberg Private WWII History Tour: Rally Grounds & Courtroom 600

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Wurzburg

5-night Frankfurt am Main to Nuremberg

Avalon · Avalon Tranquility II

4 ports
One way
Sails Dec 6, 2026
From $2,789 pp
River

Wurzburg Würzburg Residenz: Private Guided Palace & Fresco Masterpiece
Bamberg Private Walking Tour: Bamberg UNESCO Old Town Unveiled
Nuremberg Private WWII History Tour: Rally Grounds & Courtroom 600

See the whole trip →

Wurzburg

5-night Frankfurt am Main to Nuremberg

Avalon · Avalon Imagery II

4 ports
One way
Sails Dec 14, 2026
From $2,789 pp
River

Wurzburg Würzburg Residenz: Private Guided Palace & Fresco Masterpiece
Bamberg Private Walking Tour: Bamberg UNESCO Old Town Unveiled
Nuremberg Private WWII History Tour: Rally Grounds & Courtroom 600

See the whole trip →

Wurzburg

5-night Frankfurt am Main to Nuremberg

Avalon · Avalon Panorama

4 ports
One way
Sails Dec 1, 2027
From $3,529 pp
River

Wurzburg Würzburg Residenz: Private Guided Palace & Fresco Masterpiece
Bamberg Private Walking Tour: Bamberg UNESCO Old Town Unveiled
Nuremberg Private WWII History Tour: Rally Grounds & Courtroom 600

See the whole trip →

Wurzburg

5-night Frankfurt am Main to Nuremberg

Avalon · Avalon Vista

4 ports
One way
Sails Dec 4, 2027
From $3,529 pp
River

Wurzburg Würzburg Residenz: Private Guided Palace & Fresco Masterpiece
Bamberg Private Walking Tour: Bamberg UNESCO Old Town Unveiled
Nuremberg Private WWII History Tour: Rally Grounds & Courtroom 600

See the whole trip →

Wurzburg

5-night Frankfurt am Main to Nuremberg

Avalon · Avalon Passion

4 ports
One way
Sails Dec 11, 2027
From $3,179 pp
River

Wurzburg Würzburg Residenz: Private Guided Palace & Fresco Masterpiece
Bamberg Private Walking Tour: Bamberg UNESCO Old Town Unveiled
Nuremberg Private WWII History Tour: Rally Grounds & Courtroom 600

See the whole trip →

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