⚓ Cruises

Panama Canal cruises from San Antonio

4 itineraries with a bookable sailing ahead, 4 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › Panama Canal cruises from San Antonio

Cruise line

Holland America2 Azamara1 Cunard1

Most popular first

Ranked by what people search for and where the cruise lines send the most ships.

Coquimbo (La Serena)

16-night San Antonio to Fort Lauderdale (Port Everglades)

Holland America · Oosterdam

10 ports
One way
Sails Mar 24, 2027
From $2,299 pp
Premium

Coquimbo (La Serena) Elqui Valley: Pisco Distillery, Vineyards & Stargazing
General San Martin Ballestas Islands: Private Wildlife Boat Expedition
Callao (Lima) Palomino Islands: Swim with Sea Lions in the Pacific

See the whole trip →

Coquimbo (La Serena)

17-night San Antonio to Fort Lauderdale (Port Everglades)

Holland America · Nieuw Amsterdam

10 ports
One way
Sails Mar 21, 2028
From $2,894 pp
Premium

Coquimbo (La Serena) Elqui Valley: Pisco Distillery, Vineyards & Stargazing
General San Martin Ballestas Islands: Private Wildlife Boat Expedition
Callao (Lima) Palomino Islands: Swim with Sea Lions in the Pacific

See the whole trip →

Coquimbo (La Serena)

19-night San Antonio to Miami

Azamara · Azamara Journey

12 ports
Repositioning
Sails Mar 10, 2027
From $5,847 pp
Luxury

Coquimbo (La Serena) Elqui Valley: Pisco Distillery, Vineyards & Stargazing
Iquique Humberstone & Santa Laura: Private UNESCO Desert Ghost Town Tour
Arica Lauca National Park & Chungará Lake Full-Day Private Tour

See the whole trip →

Coquimbo (La Serena)

19-night San Antonio to Fort Lauderdale (Port Everglades)

Cunard · Queen Anne

9 ports
One way
Sails Feb 28, 2027
From $2,699 pp
Premium

Coquimbo (La Serena) Elqui Valley: Pisco Distillery, Vineyards & Stargazing
Arica Lauca National Park & Chungará Lake Full-Day Private Tour
Callao (Lima) Palomino Islands: Swim with Sea Lions in the Pacific

See the whole trip →

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