⚓ Cruises

South America cruises

260 itineraries with a bookable sailing ahead, 555 sailings, most popular first. Each card: how long, how many ports, when, from what price — and the bucket-list thing to do at every stop.

All cruises › South America cruises

Sailing from

Buenos Aires63 Santos (Sao Paulo)62 Rio de Janeiro43 Itajai22 Montevideo16 Camboriú12 Paranagua10 Bahia de Salvador9 Valparaiso (Santiago)7 Maceio4 San Antonio3 Buenos Aires2 Lima2 Callao (Lima)2

Cruise line

MSC Cruises153 Princess4 Celebrity9 Viking Ocean12 Oceania5 Holland America3 Silversea3 Regent3 Azamara2 Cunard1 Costa63 Avalon2

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Ranked by what people search for and where the cruise lines send the most ships.

Rio de Janeiro

9-night South America from Buenos Aires

MSC Cruises · MSC Splendida

6 ports
Round trip
2 departures Dec 2027 – Jan 2028
From $1,300 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

Buzios

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

6 ports
Round trip
2 departures Jan 2028
From $1,247 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Buenos Aires

9-night South America from Rio de Janeiro

MSC Cruises · MSC Splendida

5 ports
Round trip
2 departures Dec 2026
From $1,676 pp
Contemporary

Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Santos (Sao Paulo)

1-night Rio de Janeiro to Santos (Sao Paulo)

MSC Cruises · MSC Divina

2 ports
One way
Sails Nov 15, 2026
From $83 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Santos (Sao Paulo)

1-night Rio de Janeiro to Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

2 ports
One way
Sails Dec 1, 2026
From $70 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Buzios

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

3 ports
Round trip
2 departures Jan – Feb 2028
From $479 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Porto Belo (Santa Catarina) Ilha de Porto Belo: Private Ecological Island Boat Tour

See the whole trip →

Buzios

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

2 ports
Round trip
Sails Nov 29, 2026
From $529 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

Buzios

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

2 ports
Round trip
Sails Dec 2, 2026
From $428 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves

See the whole trip →

Camboriú

6-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Meraviglia

3 ports
Round trip
Sails Jan 3, 2028
From $919 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Buenos Aires

6-night South America from Camboriú

MSC Cruises · MSC Meraviglia

3 ports
Round trip
Sails Jan 4, 2028
From $969 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Buzios

6-night South America from Rio de Janeiro

MSC Cruises · MSC Musica

5 ports
Round trip
2 departures Dec 2027 – Jan 2028
From $809 pp
Contemporary

Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Paranagua Serra Verde Express: Private Gold-Class Train to Curitiba
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

Montevideo

4-night Rio de Janeiro to Buenos Aires

MSC Cruises · MSC Splendida

3 ports
One way
Sails Nov 29, 2026
From $1,589 pp
Contemporary

Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Rio de Janeiro

4-night Bahia de Salvador to Santos (Sao Paulo)

MSC Cruises · MSC Divina

3 ports
One way
Sails Nov 12, 2026
From $854 pp
Contemporary

Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Rio de Janeiro

4-night Bahia de Salvador to Santos (Sao Paulo)

MSC Cruises · MSC Virtuosa

3 ports
One way
Sails Nov 28, 2026
From $729 pp
Contemporary

Bahia de Salvador Pelourinho Private Walking Tour with Ivan Bahia Guide
Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Ilhabela

2-night Santos (Sao Paulo) to Rio de Janeiro

MSC Cruises · MSC Musica

3 ports
One way
Sails Dec 20, 2026
From $509 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches
Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón

See the whole trip →

Ilhabela

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

2 ports
Round trip
Sails Jan 26, 2027
From $569 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Ilhabela Private Superboat to Castelhanos & Hidden Atlantic Forest Beaches

See the whole trip →

Santos (Sao Paulo)

7-night South America from Buenos Aires

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Jan 7, 2027
From $1,477 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Camboriú

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Jan 10, 2027
From $1,439 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Montevideo

7-night South America from Camboriú

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Jan 11, 2027
From $1,519 pp
Contemporary

Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Montevideo

7-night South America from Buenos Aires

MSC Cruises · MSC Meraviglia

4 ports
Round trip
Sails Dec 23, 2027
From $1,129 pp
Contemporary

Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Camboriú

3-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

2 ports
Round trip
Sails Dec 2, 2026
From $529 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Buzios

4-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Divina

3 ports
Round trip
Sails Jan 27, 2028
From $519 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Buzios Private Catamaran Cruise: Buzios' 20 Beaches & Hidden Coves
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Santos (Sao Paulo)

1-night Itajai to Santos (Sao Paulo)

MSC Cruises · MSC Musica

2 ports
One way
Sails Mar 14, 2027
From $209 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Santos (Sao Paulo)

7-night South America from Buenos Aires

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Dec 10, 2026
From $1,397 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Punta del Este

7-night South America from Camboriú

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Dec 14, 2026
From $1,299 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Punta del Este

7-night South America from Camboriú

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Dec 28, 2026
From $1,519 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Santos (Sao Paulo)

7-night South America from Buenos Aires

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Jan 14, 2027
From $1,407 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Camboriú

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Jan 24, 2027
From $1,379 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Camboriú

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Jan 31, 2027
From $1,299 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Camboriú

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Feb 7, 2027
From $1,369 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Santos (Sao Paulo)

7-night South America from Buenos Aires

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Feb 11, 2027
From $1,357 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Santos (Sao Paulo)

7-night South America from Buenos Aires

MSC Cruises · MSC Seaview

4 ports
Round trip
Sails Feb 25, 2027
From $1,407 pp
Contemporary

Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Camboriú

7-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Meraviglia

4 ports
Round trip
Sails Dec 27, 2027
From $1,549 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup

See the whole trip →

Buenos Aires

7-night South America from Camboriú

MSC Cruises · MSC Meraviglia

4 ports
Round trip
Sails Dec 28, 2027
From $1,609 pp
Contemporary

Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast

See the whole trip →

Punta del Este

7-night South America from Buenos Aires

MSC Cruises · MSC Meraviglia

4 ports
Round trip
Sails Dec 30, 2027
From $1,648 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride

See the whole trip →

Camboriú

5-night Santos (Sao Paulo) to Buenos Aires

MSC Cruises · MSC Seaview

5 ports
One way
Sails Dec 5, 2026
From $956 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Punta del Este

8-night South America from Camboriú

MSC Cruises · MSC Seaview

5 ports
Round trip
Sails Dec 6, 2026
From $1,029 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Camboriú

8-night South America from Santos (Sao Paulo)

MSC Cruises · MSC Meraviglia

5 ports
Round trip
Sails Dec 19, 2027
From $1,209 pp
Contemporary

Camboriú Unipraias Park: Private Cable Car, Zipline & Sled Ride
Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket

See the whole trip →

Punta del Este

8-night South America from Camboriú

MSC Cruises · MSC Meraviglia

5 ports
Round trip
Sails Dec 20, 2027
From $1,259 pp
Contemporary

Punta del Este Punta del Este Private Sightseeing Tour with Port Pickup
Buenos Aires El Teatro Colón: Guided Tour + Premium Performance Ticket
Montevideo Mercado del Puerto: Private Asado Feast & Grill Master Tour

See the whole trip →

Maceio

8-night South America from Bahia de Salvador

MSC Cruises · MSC Virtuosa

5 ports
Round trip
Sails Mar 21, 2028
From $1,065 pp
Contemporary

Maceio Praia do Gunga: Private Jangada & Secluded Beach Day
Santos (Sao Paulo) Private Santos Full-Day: Coffee Museum, Monte Serrat & Coast
Rio de Janeiro Private Full-Day Rio Highlights: Christ, Sugarloaf & Selarón

See the whole trip →

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