Bucket-List Cruise Adventures

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Bucket-list adventures at every port — where to fly in, and what to do the day(s) before and after.

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Filtering South America ×Caribbean ×From Panama City, Panama × Clear all
Showing 13 of 13 sailings
Viking Ocean · Viking MarsOne-way
Caribbean 10 nights Nov 13 – Nov 23, 2026 from Panama City, Panama to Fort Lauderdale (Port Everglades), Florida
Panama City, Panama · Scenic Sailing: Panama Canal · … · Fort Lauderdale (Port Everglades), Florida10 ports
Panama City, Panama · Scenic Sailing: Panama Canal · Colon, Panama · Puerto Limon, Costa Rica · Sail the Caribbean Sea · Roatan, Honduras · Belize City, Belize · Cozumel, Mexico · Sail the Caribbean Sea · Fort Lauderdale (Port Everglades), Florida
★ Bucket-list Panama Canal Miraflores LocksPanama Canal Full TransitVeragua Rainforest ParkHold a Sloth at Daniel Johnson's Monkey & Sloth Ha… +3 more
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from $4,599
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Viking Ocean · Viking MarsOne-way
Panama Canal 10 nights Dec 17 – Dec 27, 2026 from Panama City, Panama to West Palm Beach (Port of Palm Beach), Florida
Panama City, Panama · Scenic Sailing: Panama Canal · … · West Palm Beach (Port of Palm Beach), Florida10 ports
Panama City, Panama · Scenic Sailing: Panama Canal · Colon, Panama · Puerto Limon, Costa Rica · Sail the Caribbean Sea · Roatan, Honduras · Belize City, Belize · Cozumel, Mexico · Sail the Caribbean Sea · West Palm Beach (Port of Palm Beach), Florida
★ Bucket-list Panama Canal Miraflores LocksPanama Canal Full TransitVeragua Rainforest ParkHold a Sloth at Daniel Johnson's Monkey & Sloth Ha… +2 more
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from $3,699
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Oceania · Oceania MarinaOne-way
Panama Canal 10 nights Jan 15 – Jan 25, 2027 from Panama City, Panama to Miami, Florida
Panama City, Panama · Kiel Canal, Germany · … · Miami, Florida9 ports
Panama City, Panama · Kiel Canal, Germany · Cartagena, Colombia · Santa Marta, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Falmouth, Jamaica · Georgetown, Grand Cayman, Cayman Islands · Miami, Florida
★ Bucket-list Panama Canal Miraflores LocksPrivate Expert Walking Tour of KielThe Roman Theatre of Cartagena with the Rafael Mon…Aruba +4 more
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from $5,099
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Regent · Seven Seas SplendorOne-way
Pacific 28 nights Jan 26 – Feb 23, 2027 from Panama City, Panama to Papeete, Tahiti, French Polynesia
Panama City, Panama · Willis Island · … · Papeete, Tahiti, French Polynesia19 ports
Panama City, Panama · Willis Island · Puntarenas, Costa Rica · Willis Island · Acajutla, El Salvador · Puerto Quetzal, Guatemala · Willis Island · Puerto Vallarta, Mexico · Cabo San Lucas, Mexico · Willis Island · Los Angeles, California · Willis Island · Honolulu, Oahu, Hawaii · Kahului, Maui, Hawaii · Hilo, Hawaii · Willis Island · Bora Bora, French Polynesia · Moorea, French Polynesia · Papeete, Tahiti, French Polynesia
★ Bucket-list Panama Canal Miraflores LocksZodiac Circumnavigation of Willis IslandMonteverde Cloud ForestTazumal Mayan Ruins +10 more
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from $17,710
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Regent · Seven Seas GrandeurRound-trip
Caribbean 22 nights Mar 9 – Mar 31, 2027 from Panama City, Panama
Panama City, Panama · Panama Canal, Panama · … · Panama City, Panama17 ports
Panama City, Panama · Panama Canal, Panama · Willis Island · Oranjestad, Sint Eustatius · Willis Island · Port of Spain, Trinidad · Willis Island · Manaus, Brazil · Boca da Valeria, Brazil · Alter do Chao, Brazil · Willis Island · St. Georges, Grenada, West Indies · Willis Island · Willemstad, Curacao · Willis Island · Panama Canal, Panama · Panama City, Panama
★ Bucket-list Panama Canal Miraflores LocksPanama Canal Full TransitZodiac Circumnavigation of Willis IslandThe Natural Pool +3 more
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from $20,949
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Oceania · Oceania MarinaOne-way
Panama Canal 10 nights Mar 15 – Mar 25, 2027 from Panama City, Panama to Miami, Florida
Panama City, Panama · Kiel Canal, Germany · … · Miami, Florida9 ports
Panama City, Panama · Kiel Canal, Germany · Cartagena, Colombia · Santa Marta, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Falmouth, Jamaica · Georgetown, Grand Cayman, Cayman Islands · Miami, Florida
★ Bucket-list Panama Canal Miraflores LocksPrivate Expert Walking Tour of KielThe Roman Theatre of Cartagena with the Rafael Mon…Aruba +4 more
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from $2,640
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Regent · Seven Seas GrandeurOne-way
Mediterranean 14 nights Mar 31 – Apr 14, 2027 from Panama City, Panama to Miami, Florida
Panama City, Panama · Kiel Canal, Germany · … · Miami, Florida14 ports
Panama City, Panama · Kiel Canal, Germany · Cartagena, Spain · Santa Marta, Colombia · Oranjestad, Sint Eustatius · Willemstad, Curacao · Kralendijk, Bonaire, Dutch Antilles · Willis Island · St. Georges, Grenada, West Indies · Castries, St. Lucia · Gustavia, St. Barts · Tortola, B.V.I. · Willis Island · Miami, Florida
★ Bucket-list Panama Canal Miraflores LocksPrivate Expert Walking Tour of KielThe Roman Theatre of Cartagena with the Rafael Mon…The Natural Pool +8 more
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from $8,699
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Viking Ocean · Viking MarsOne-way
Caribbean 10 nights Nov 29 – Dec 9, 2027 from Panama City, Panama to Fort Lauderdale (Port Everglades), Florida
Panama City, Panama · Scenic Sailing: Panama Canal · … · Fort Lauderdale (Port Everglades), Florida10 ports
Panama City, Panama · Scenic Sailing: Panama Canal · Colon, Panama · Puerto Limon, Costa Rica · Sail the Caribbean Sea · Belize City, Belize · Cozumel, Mexico · Merida, Mexico · Sail the Caribbean Sea · Fort Lauderdale (Port Everglades), Florida
★ Bucket-list Panama Canal Miraflores LocksPanama Canal Full TransitVeragua Rainforest ParkGreat Blue Hole Flightseeing & Lighthouse Reef Sno… +2 more
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from $3,999
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Azamara · Azamara QuestOne-way
Panama Canal 10 nights Jan 14 – Jan 24, 2028 from Panama City, Panama to Valparaiso (Santiago), Chile
Panama City, Panama · Manta (Quito), Ecuador · … · Valparaiso (Santiago), Chile6 ports
Panama City, Panama · Manta (Quito), Ecuador · Callao (Lima), Peru · Pisco (Puerto San Martin), Peru · Coquimbo (La Serena), Chile · Valparaiso (Santiago), Chile
★ Bucket-list Panama Canal Miraflores LocksPalomino IslandsBallestas IslandsElqui Valley
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from $3,799
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Oceania · Oceania MarinaOne-way
Caribbean 10 nights Jan 16 – Jan 26, 2028 from Panama City, Panama to Miami, Florida
Panama City, Panama · Kiel Canal, Germany · … · Miami, Florida10 ports
Panama City, Panama · Kiel Canal, Germany · Cartagena, Colombia · Suez Canal, Egypt · Willemstad, Curacao · Port of Oranjestad, Aruba, Caribbean · Montego Bay, Jamaica · Georgetown, Grand Cayman, Cayman Islands · Suez Canal, Egypt · Miami, Florida
★ Bucket-list Panama Canal Miraflores LocksPrivate Expert Walking Tour of KielThe Roman Theatre of Cartagena with the Rafael Mon…Private Giza Pyramids, Sphinx & Valley Temple Day… +5 more
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from $3,099
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Viking Ocean · Viking MarsOne-way
Mexico 10 nights Jan 16 – Jan 26, 2028 from Panama City, Panama to Fort Lauderdale (Port Everglades), Florida
Panama City, Panama · Scenic Sailing: Panama Canal · … · Fort Lauderdale (Port Everglades), Florida10 ports
Panama City, Panama · Scenic Sailing: Panama Canal · Colon, Panama · Puerto Limon, Costa Rica · Sail the Caribbean Sea · Belize City, Belize · Cozumel, Mexico · Merida, Mexico · Sail the Caribbean Sea · Fort Lauderdale (Port Everglades), Florida
★ Bucket-list Panama Canal Miraflores LocksPanama Canal Full TransitVeragua Rainforest ParkGreat Blue Hole Flightseeing & Lighthouse Reef Sno… +2 more
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from $4,499
Book This Cruise@ Cruisebound
Regent · Seven Seas PrestigeOne-way
Mediterranean 12 nights Mar 14 – Mar 26, 2028 from Panama City, Panama to Miami, Florida
Panama City, Panama · Kiel Canal, Germany · … · Miami, Florida12 ports
Panama City, Panama · Kiel Canal, Germany · Cartagena, Spain · Willis Island · Oranjestad, Sint Eustatius · Willemstad, Curacao · Willis Island · St. Georges, Grenada, West Indies · Roseau, Dominica · Charlotte Amalie, St. Thomas, U.S. Virgin Islands · Willis Island · Miami, Florida
★ Bucket-list Panama Canal Miraflores LocksPrivate Expert Walking Tour of KielThe Roman Theatre of Cartagena with the Rafael Mon…Zodiac Circumnavigation of Willis Island +6 more
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from $8,599
Book This Cruise@ Cruisebound
Oceania · Oceania MarinaOne-way
Caribbean 10 nights Mar 15 – Mar 25, 2028 from Panama City, Panama to Miami, Florida
Panama City, Panama · Kiel Canal, Germany · … · Miami, Florida9 ports
Panama City, Panama · Kiel Canal, Germany · Puerto Limon, Costa Rica · Roatan, Honduras · Santo Tomas de Castilla, Guatemala · Costa Maya, Mexico · Cozumel, Mexico · Suez Canal, Egypt · Miami, Florida
★ Bucket-list Panama Canal Miraflores LocksPrivate Expert Walking Tour of KielVeragua Rainforest ParkHold a Sloth at Daniel Johnson's Monkey & Sloth Ha… +5 more
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from $2,999
Book This Cruise@ Cruisebound

Itineraries from the Cruisebound catalog + our enrichment; schedules cross-checked against official port authorities. Booking via Cruisebound and CruiseDirect — we may earn a commission, at no extra cost to you.

19 lines
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MSC Cruises Royal Caribbean Carnival Viking River Costa Norwegian AmaWaterways Princess Celebrity Viking Ocean Avalon Disney Holland America Oceania Virgin Voyages Regent Cunard Seabourn Azamara