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Showing 36 of 3,611 sailings

Costa · Costa FascinosaOne-way

Mediterranean 5 nights Sep 17 – Sep 22, 2026 from Naples, Italy to Barcelona, Spain

Naples, Italy · Civitavecchia (Rome), Italy · … · Barcelona, Spain6 ports

Naples, Italy · Civitavecchia (Rome), Italy · Ajaccio, Corsica, France · Savona (Genoa), Italy · Marseille, France · Barcelona, Spain

★ Bucket-list Pompeii with a Licensed Archaeologist Vatican, Sistine Chapel & Colosseum in One Day Sanguinaires Islands & Calanques Portofino & San Fruttuoso Abbey by the local ferry +2 more

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from $573

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Costa · Costa SmeraldaRound-trip

Mediterranean 7 nights Sep 17 – Sep 24, 2026 from Palermo, Sicily, Italy

Palermo, Sicily, Italy · Civitavecchia (Rome), Italy · … · Palermo, Sicily, Italy9 ports

Palermo, Sicily, Italy · Civitavecchia (Rome), Italy · Savona (Genoa), Italy · Marseille, France · Barcelona, Spain · Balearic sea darkest spot · Ibiza, Spain · Balearic sea darkest spot · Palermo, Sicily, Italy

★ Bucket-list Cappella Palatina & the Norman Palace Vatican, Sistine Chapel & Colosseum in One Day Portofino & San Fruttuoso Abbey by the local ferry Calanques National Park Boat Cruise from the Old P… +2 more

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from $1,103

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Costa · Costa ToscanaRound-trip

Mediterranean 7 nights Sep 17 – Sep 24, 2026 from Civitavecchia (Rome), Italy

Civitavecchia (Rome), Italy · Genoa, Italy · … · Civitavecchia (Rome), Italy8 ports

Civitavecchia (Rome), Italy · Genoa, Italy · Marseille, France · Barcelona, Spain · Balearic sea darkest spot · Cagliari, Sardinia, Italy · Naples, Italy · Civitavecchia (Rome), Italy

★ Bucket-list Vatican, Sistine Chapel & Colosseum in One Day Sail straight to Portofino from the cruise dock Calanques National Park Boat Cruise from the Old P…Sagrada Familia +2 more

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from $755

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MSC Cruises · MSC OperaRound-trip

Mediterranean 10 nights Sep 17 – Sep 27, 2026 from Alicante, Spain

Alicante, Spain · Mahon, Minorca, Spain · … · Alicante, Spain9 ports

Alicante, Spain · Mahon, Minorca, Spain · Olbia, Italy · Genoa, Italy · Marseille, France · Malaga, Spain · Cadiz (Seville), Spain · Lisbon, Portugal · Alicante, Spain

★ Bucket-list Castillo de Santa Bárbara Private Catamaran Sail Tavolara Island Sail straight to Portofino from the cruise dock +4 more

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from $1,596

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MSC Cruises · MSC OrchestraRound-trip

Mediterranean 7 nights Sep 17 – Sep 24, 2026 from Marseille, France

Marseille, France · Tarragona, Spain · … · Marseille, France7 ports

Marseille, France · Tarragona, Spain · Valencia, Spain · Livorno (Florence/Pisa), Italy · Civitavecchia (Rome), Italy · Genoa, Italy · Marseille, France

★ Bucket-list Calanques National Park Boat Cruise from the Old P…Private Roman Tarraco Oceanografic Climb the Leaning Tower of Pisa +2 more

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from $894

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MSC Cruises · MSC SeaviewRound-trip

Mediterranean 7 nights Sep 17 – Sep 24, 2026 from Barcelona, Spain

Barcelona, Spain · Marseille, France · … · Barcelona, Spain7 ports

Barcelona, Spain · Marseille, France · Genoa, Italy · Civitavecchia (Rome), Italy · Palermo, Sicily, Italy · Ibiza, Spain · Barcelona, Spain

★ Bucket-list Sagrada Familia Calanques National Park Boat Cruise from the Old P…Sail straight to Portofino from the cruise dock Vatican, Sistine Chapel & Colosseum in One Day +2 more

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from $1,231

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Costa · Costa FascinosaRound-trip

Mediterranean 15 nights Sep 18 – Oct 3, 2026 from Civitavecchia (Rome), Italy

Civitavecchia (Rome), Italy · Ajaccio, Corsica, France · … · Civitavecchia (Rome), Italy13 ports

Civitavecchia (Rome), Italy · Ajaccio, Corsica, France · Savona (Genoa), Italy · Marseille, France · Barcelona, Spain · Palma de Mallorca, Spain · Valletta, Malta · Santorini (Thira), Greece · Mykonos, Greece · Piraeus (Athens), Greece · Souda Bay · Messina, Sicily, Italy · Civitavecchia (Rome), Italy

★ Bucket-list Vatican, Sistine Chapel & Colosseum in One Day Sanguinaires Islands & Calanques Portofino & San Fruttuoso Abbey by the local ferry Calanques National Park Boat Cruise from the Old P… +8 more

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from $1,927

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Costa · Costa SmeraldaRound-trip

Mediterranean 7 nights Sep 18 – Sep 25, 2026 from Civitavecchia (Rome), Italy

Civitavecchia (Rome), Italy · Savona (Genoa), Italy · … · Civitavecchia (Rome), Italy9 ports

Civitavecchia (Rome), Italy · Savona (Genoa), Italy · Marseille, France · Barcelona, Spain · Balearic sea darkest spot · Ibiza, Spain · Balearic sea darkest spot · Palermo, Sicily, Italy · Civitavecchia (Rome), Italy

★ Bucket-list Vatican, Sistine Chapel & Colosseum in One Day Portofino & San Fruttuoso Abbey by the local ferry Calanques National Park Boat Cruise from the Old P…Sagrada Familia +2 more

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from $655

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Costa · Costa ToscanaRound-trip

Mediterranean 7 nights Sep 18 – Sep 25, 2026 from Genoa, Italy

Genoa, Italy · Marseille, France · … · Genoa, Italy8 ports

Genoa, Italy · Marseille, France · Barcelona, Spain · Balearic sea darkest spot · Cagliari, Sardinia, Italy · Naples, Italy · Civitavecchia (Rome), Italy · Genoa, Italy

★ Bucket-list Sail straight to Portofino from the cruise dock Calanques National Park Boat Cruise from the Old P…Sagrada Familia Su Nuraxi di Barumini +2 more

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from $721

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MSC Cruises · MSC GrandiosaRound-trip

Mediterranean 7 nights Sep 18 – Sep 25, 2026 from Palma de Mallorca, Spain

Palma de Mallorca, Spain · Barcelona, Spain · … · Palma de Mallorca, Spain7 ports

Palma de Mallorca, Spain · Barcelona, Spain · Cannes, France · Genoa, Italy · La Spezia (Cinque Terre), Italy · Civitavecchia (Rome), Italy · Palma de Mallorca, Spain

★ Bucket-list La Seu Cathedral + Rooftop Terraces Climb Sagrada Familia Private Boat to Îles de Lérins Sail straight to Portofino from the cruise dock +2 more

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from $1,155

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MSC Cruises · MSC OrchestraRound-trip

Mediterranean 7 nights Sep 18 – Sep 25, 2026 from Tarragona, Spain

Tarragona, Spain · Valencia, Spain · … · Tarragona, Spain7 ports

Tarragona, Spain · Valencia, Spain · Livorno (Florence/Pisa), Italy · Civitavecchia (Rome), Italy · Genoa, Italy · Marseille, France · Tarragona, Spain

★ Bucket-list Private Roman Tarraco Oceanografic Climb the Leaning Tower of Pisa Vatican, Sistine Chapel & Colosseum in One Day +2 more

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from $890

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MSC Cruises · MSC SeaviewRound-trip

Mediterranean 7 nights Sep 18 – Sep 25, 2026 from Marseille, France

Marseille, France · Genoa, Italy · … · Marseille, France7 ports

Marseille, France · Genoa, Italy · Civitavecchia (Rome), Italy · Palermo, Sicily, Italy · Ibiza, Spain · Barcelona, Spain · Marseille, France

★ Bucket-list Calanques National Park Boat Cruise from the Old P…Sail straight to Portofino from the cruise dock Vatican, Sistine Chapel & Colosseum in One Day Cappella Palatina & the Norman Palace +2 more

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from $1,075

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MSC Cruises · MSC World EuropaRound-trip

Mediterranean 7 nights Sep 18 – Sep 25, 2026 from Barcelona, Spain

Barcelona, Spain · Marseille, France · … · Barcelona, Spain7 ports

Barcelona, Spain · Marseille, France · Genoa, Italy · Naples, Italy · Messina, Sicily, Italy · Valletta, Malta · Barcelona, Spain

★ Bucket-list Sagrada Familia Calanques National Park Boat Cruise from the Old P…Sail straight to Portofino from the cruise dock Pompeii with a Licensed Archaeologist +2 more

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from $1,382

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Costa · Costa PacificaRound-trip

Mediterranean 7 nights Sep 19 – Sep 26, 2026 from Civitavecchia (Rome), Italy

Civitavecchia (Rome), Italy · Savona (Genoa), Italy · … · Civitavecchia (Rome), Italy10 ports

Civitavecchia (Rome), Italy · Savona (Genoa), Italy · Toulon, France · Palma bay · Palma de Mallorca, Spain · Valencia, Spain · Palma bay · Balearic sea darkest spot · Olbia, Italy · Civitavecchia (Rome), Italy

★ Bucket-list Vatican, Sistine Chapel & Colosseum in One Day Portofino & San Fruttuoso Abbey by the local ferry Mont Faron La Seu Cathedral + Rooftop Terraces Climb +2 more

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from $859

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Costa · Costa SmeraldaRound-trip

Mediterranean 7 nights Sep 19 – Sep 26, 2026 from Savona (Genoa), Italy

Savona (Genoa), Italy · Marseille, France · … · Savona (Genoa), Italy9 ports

Savona (Genoa), Italy · Marseille, France · Barcelona, Spain · Balearic sea darkest spot · Ibiza, Spain · Balearic sea darkest spot · Palermo, Sicily, Italy · Civitavecchia (Rome), Italy · Savona (Genoa), Italy

★ Bucket-list Portofino & San Fruttuoso Abbey by the local ferry Calanques National Park Boat Cruise from the Old P…Sagrada Familia Formentera Day Trip & Ses Illetes, the 'Spanish Ca… +2 more

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from $641

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MSC Cruises · MSC GrandiosaRound-trip

Mediterranean 7 nights Sep 19 – Sep 26, 2026 from Barcelona, Spain

Barcelona, Spain · Cannes, France · … · Barcelona, Spain7 ports

Barcelona, Spain · Cannes, France · Genoa, Italy · La Spezia (Cinque Terre), Italy · Civitavecchia (Rome), Italy · Palma de Mallorca, Spain · Barcelona, Spain

★ Bucket-list Sagrada Familia Private Boat to Îles de Lérins Sail straight to Portofino from the cruise dock Private Cinque Terre by Minivan & Ferryboat from L… +2 more

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from $1,193

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MSC Cruises · MSC OrchestraRound-trip

Mediterranean 7 nights Sep 19 – Sep 26, 2026 from Valencia, Spain

Valencia, Spain · Livorno (Florence/Pisa), Italy · … · Valencia, Spain7 ports

Valencia, Spain · Livorno (Florence/Pisa), Italy · Civitavecchia (Rome), Italy · Genoa, Italy · Marseille, France · Tarragona, Spain · Valencia, Spain

★ Bucket-list Oceanografic Climb the Leaning Tower of Pisa Vatican, Sistine Chapel & Colosseum in One Day Sail straight to Portofino from the cruise dock +2 more

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from $2,008

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MSC Cruises · MSC SeaviewRound-trip

Mediterranean 7 nights Sep 19 – Sep 26, 2026 from Genoa, Italy

Genoa, Italy · Civitavecchia (Rome), Italy · … · Genoa, Italy7 ports

Genoa, Italy · Civitavecchia (Rome), Italy · Palermo, Sicily, Italy · Ibiza, Spain · Barcelona, Spain · Marseille, France · Genoa, Italy

★ Bucket-list Sail straight to Portofino from the cruise dock Vatican, Sistine Chapel & Colosseum in One Day Cappella Palatina & the Norman Palace Formentera Day Trip & Ses Illetes, the 'Spanish Ca… +2 more

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from $926

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MSC Cruises · MSC World EuropaRound-trip

Mediterranean 7 nights Sep 19 – Sep 26, 2026 from Marseille, France

Marseille, France · Genoa, Italy · … · Marseille, France7 ports

Marseille, France · Genoa, Italy · Naples, Italy · Messina, Sicily, Italy · Valletta, Malta · Barcelona, Spain · Marseille, France

★ Bucket-list Calanques National Park Boat Cruise from the Old P…Sail straight to Portofino from the cruise dock Pompeii with a Licensed Archaeologist Taormina's Ancient Greek Theatre, framed by Mount… +2 more

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from $3,813

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Princess · Sun PrincessOne-way

Mediterranean 7 nights Sep 19 – Sep 26, 2026 from Barcelona, Spain to Civitavecchia (Rome), Italy

Barcelona, Spain · Ibiza, Spain · … · Civitavecchia (Rome), Italy7 ports

Barcelona, Spain · Ibiza, Spain · Ajaccio, Corsica, France · Marseille, France · Genoa, Italy · La Spezia (Cinque Terre), Italy · Civitavecchia (Rome), Italy

★ Bucket-list Sagrada Familia Formentera Day Trip & Ses Illetes, the 'Spanish Ca…Sanguinaires Islands & Calanques Calanques National Park Boat Cruise from the Old P… +3 more

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from $1,039

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Costa · Costa FascinosaRound-trip

Mediterranean 14 nights Sep 20 – Oct 4, 2026 from Savona (Genoa), Italy

Savona (Genoa), Italy · Marseille, France · … · Savona (Genoa), Italy12 ports

Savona (Genoa), Italy · Marseille, France · Barcelona, Spain · Palma de Mallorca, Spain · Valletta, Malta · Santorini (Thira), Greece · Mykonos, Greece · Piraeus (Athens), Greece · Souda Bay · Messina, Sicily, Italy · Civitavecchia (Rome), Italy · Savona (Genoa), Italy

★ Bucket-list Portofino & San Fruttuoso Abbey by the local ferry Calanques National Park Boat Cruise from the Old P…Sagrada Familia La Seu Cathedral + Rooftop Terraces Climb +7 more

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from $1,457

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Costa · Costa PacificaRound-trip

Mediterranean 7 nights Sep 20 – Sep 27, 2026 from Savona (Genoa), Italy

Savona (Genoa), Italy · Toulon, France · … · Savona (Genoa), Italy10 ports

Savona (Genoa), Italy · Toulon, France · Palma bay · Palma de Mallorca, Spain · Valencia, Spain · Palma bay · Balearic sea darkest spot · Olbia, Italy · Civitavecchia (Rome), Italy · Savona (Genoa), Italy

★ Bucket-list Portofino & San Fruttuoso Abbey by the local ferry Mont Faron La Seu Cathedral + Rooftop Terraces Climb Oceanografic +2 more

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from $865

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Costa · Costa SmeraldaRound-trip

Mediterranean 7 nights Sep 20 – Sep 27, 2026 from Marseille, France

Marseille, France · Barcelona, Spain · … · Marseille, France9 ports

Marseille, France · Barcelona, Spain · Balearic sea darkest spot · Ibiza, Spain · Balearic sea darkest spot · Palermo, Sicily, Italy · Civitavecchia (Rome), Italy · Savona (Genoa), Italy · Marseille, France

★ Bucket-list Calanques National Park Boat Cruise from the Old P…Sagrada Familia Formentera Day Trip & Ses Illetes, the 'Spanish Ca…Cappella Palatina & the Norman Palace +2 more

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from $1,141

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Costa · Costa ToscanaRound-trip

Mediterranean 7 nights Sep 20 – Sep 27, 2026 from Barcelona, Spain

Barcelona, Spain · Balearic sea darkest spot · … · Barcelona, Spain8 ports

Barcelona, Spain · Balearic sea darkest spot · Cagliari, Sardinia, Italy · Naples, Italy · Civitavecchia (Rome), Italy · Genoa, Italy · Marseille, France · Barcelona, Spain

★ Bucket-list Sagrada Familia Su Nuraxi di Barumini Pompeii with a Licensed Archaeologist Vatican, Sistine Chapel & Colosseum in One Day +2 more

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from $545

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MSC Cruises · MSC GrandiosaRound-trip

Mediterranean 7 nights Sep 20 – Sep 27, 2026 from Cannes, France

Cannes, France · Genoa, Italy · … · Cannes, France7 ports

Cannes, France · Genoa, Italy · La Spezia (Cinque Terre), Italy · Civitavecchia (Rome), Italy · Palma de Mallorca, Spain · Barcelona, Spain · Cannes, France

★ Bucket-list Private Boat to Îles de Lérins Sail straight to Portofino from the cruise dock Private Cinque Terre by Minivan & Ferryboat from L…Vatican, Sistine Chapel & Colosseum in One Day +2 more

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from $1,006

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MSC Cruises · MSC OperaRound-trip

Mediterranean 10 nights Sep 20 – Sep 30, 2026 from Genoa, Italy

Genoa, Italy · Marseille, France · … · Genoa, Italy9 ports

Genoa, Italy · Marseille, France · Malaga, Spain · Cadiz (Seville), Spain · Lisbon, Portugal · Alicante, Spain · Mahon, Minorca, Spain · Olbia, Italy · Genoa, Italy

★ Bucket-list Sail straight to Portofino from the cruise dock Calanques National Park Boat Cruise from the Old P…Granada & the Alhambra Real Alcázar de Sevilla +4 more

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from $1,553

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MSC Cruises · MSC SeaviewRound-trip

Mediterranean 7 nights Sep 20 – Sep 27, 2026 from Civitavecchia (Rome), Italy

Civitavecchia (Rome), Italy · Palermo, Sicily, Italy · … · Civitavecchia (Rome), Italy7 ports

Civitavecchia (Rome), Italy · Palermo, Sicily, Italy · Ibiza, Spain · Barcelona, Spain · Marseille, France · Genoa, Italy · Civitavecchia (Rome), Italy

★ Bucket-list Vatican, Sistine Chapel & Colosseum in One Day Cappella Palatina & the Norman Palace Formentera Day Trip & Ses Illetes, the 'Spanish Ca…Sagrada Familia +2 more

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from $1,320

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MSC Cruises · MSC World EuropaRound-trip

Mediterranean 7 nights Sep 20 – Sep 27, 2026 from Genoa, Italy

Genoa, Italy · Naples, Italy · … · Genoa, Italy7 ports

Genoa, Italy · Naples, Italy · Messina, Sicily, Italy · Valletta, Malta · Barcelona, Spain · Marseille, France · Genoa, Italy

★ Bucket-list Sail straight to Portofino from the cruise dock Pompeii with a Licensed Archaeologist Taormina's Ancient Greek Theatre, framed by Mount…St John's Co-Cathedral & the Caravaggio masterpieces +2 more

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from $4,232

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Costa · Costa DiademaOne-way

Mediterranean 2 nights Sep 21 – Sep 23, 2026 from Barcelona, Spain to Savona (Genoa), Italy

Barcelona, Spain · Marseille, France · Savona (Genoa), Italy

★ Bucket-list Sagrada Familia Calanques National Park Boat Cruise from the Old P…Portofino & San Fruttuoso Abbey by the local ferry

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from $316

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Costa · Costa FascinosaRound-trip

Mediterranean 16 nights Sep 21 – Oct 7, 2026 from Marseille, France

Marseille, France · Barcelona, Spain · … · Marseille, France13 ports

Marseille, France · Barcelona, Spain · Palma de Mallorca, Spain · Valletta, Malta · Santorini (Thira), Greece · Mykonos, Greece · Piraeus (Athens), Greece · Souda Bay · Messina, Sicily, Italy · Civitavecchia (Rome), Italy · Savona (Genoa), Italy · Barcelona, Spain · Marseille, France

★ Bucket-list Calanques National Park Boat Cruise from the Old P…Sagrada Familia La Seu Cathedral + Rooftop Terraces Climb St John's Co-Cathedral & the Caravaggio masterpieces +7 more

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from $2,179

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Costa · Costa PacificaRound-trip

Mediterranean 7 nights Sep 21 – Sep 28, 2026 from Toulon, France

Toulon, France · Palma de Mallorca, Spain · … · Toulon, France10 ports

Toulon, France · Palma de Mallorca, Spain · Palma bay · Valencia, Spain · Palma bay · Balearic sea darkest spot · Olbia, Italy · Civitavecchia (Rome), Italy · Savona (Genoa), Italy · Toulon, France

★ Bucket-list Mont Faron La Seu Cathedral + Rooftop Terraces Climb Oceanografic Tavolara Island +2 more

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from $1,070

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Costa · Costa SmeraldaRound-trip

Mediterranean 7 nights Sep 21 – Sep 28, 2026 from Barcelona, Spain

Barcelona, Spain · Balearic sea darkest spot · … · Barcelona, Spain9 ports

Barcelona, Spain · Balearic sea darkest spot · Ibiza, Spain · Balearic sea darkest spot · Palermo, Sicily, Italy · Civitavecchia (Rome), Italy · Savona (Genoa), Italy · Marseille, France · Barcelona, Spain

★ Bucket-list Sagrada Familia Formentera Day Trip & Ses Illetes, the 'Spanish Ca…Cappella Palatina & the Norman Palace Vatican, Sistine Chapel & Colosseum in One Day +2 more

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from $835

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MSC Cruises · MSC GrandiosaRound-trip

Mediterranean 7 nights Sep 21 – Sep 28, 2026 from Genoa, Italy

Genoa, Italy · La Spezia (Cinque Terre), Italy · … · Genoa, Italy7 ports

Genoa, Italy · La Spezia (Cinque Terre), Italy · Civitavecchia (Rome), Italy · Palma de Mallorca, Spain · Barcelona, Spain · Cannes, France · Genoa, Italy

★ Bucket-list Sail straight to Portofino from the cruise dock Private Cinque Terre by Minivan & Ferryboat from L…Vatican, Sistine Chapel & Colosseum in One Day La Seu Cathedral + Rooftop Terraces Climb +2 more

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from $1,011

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MSC Cruises · MSC OperaRound-trip

Mediterranean 10 nights Sep 21 – Oct 1, 2026 from Marseille, France

Marseille, France · Malaga, Spain · … · Marseille, France9 ports

Marseille, France · Malaga, Spain · Cadiz (Seville), Spain · Lisbon, Portugal · Alicante, Spain · Mahon, Minorca, Spain · Olbia, Italy · Genoa, Italy · Marseille, France

★ Bucket-list Calanques National Park Boat Cruise from the Old P…Granada & the Alhambra Real Alcázar de Sevilla Sintra +4 more

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from $1,384

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MSC Cruises · MSC SeaviewRound-trip

Mediterranean 7 nights Sep 21 – Sep 28, 2026 from Palermo, Sicily, Italy

Palermo, Sicily, Italy · Ibiza, Spain · … · Palermo, Sicily, Italy7 ports

Palermo, Sicily, Italy · Ibiza, Spain · Barcelona, Spain · Marseille, France · Genoa, Italy · Civitavecchia (Rome), Italy · Palermo, Sicily, Italy

★ Bucket-list Cappella Palatina & the Norman Palace Formentera Day Trip & Ses Illetes, the 'Spanish Ca…Sagrada Familia Calanques National Park Boat Cruise from the Old P… +2 more

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from $3,950

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MSC Cruises · MSC World EuropaRound-trip

Mediterranean 7 nights Sep 21 – Sep 28, 2026 from Naples, Italy

Naples, Italy · Messina, Sicily, Italy · … · Naples, Italy7 ports

Naples, Italy · Messina, Sicily, Italy · Valletta, Malta · Barcelona, Spain · Marseille, France · Genoa, Italy · Naples, Italy

★ Bucket-list Pompeii with a Licensed Archaeologist Taormina's Ancient Greek Theatre, framed by Mount…St John's Co-Cathedral & the Caravaggio masterpieces Sagrada Familia +2 more

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from $1,237

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Itineraries from the Cruisebound catalog + our enrichment; schedules cross-checked against official port authorities. Booking via Cruisebound and CruiseDirect — we may earn a commission, at no extra cost to you.

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MSC Cruises Royal Caribbean Carnival Viking River Norwegian AmaWaterways Costa Princess Celebrity Avalon Disney Viking Ocean Holland America Silversea Oceania Virgin Regent Explora Journeys Cunard Azamara Windstar Seabourn Virgin Voyages