Bucket-List Cruise Adventures

Cruises from Colon, Panama

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Filtering From Colon, Panama × Clear all
Showing 36 of 51 sailings
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Sep 19 – Sep 26, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,022
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Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Sep 26 – Oct 3, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,257
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Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Oct 3 – Oct 10, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $2,196
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Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Oct 10 – Oct 17, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $996
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Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Oct 17 – Oct 24, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,085
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Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Oct 24 – Oct 31, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,066
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Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Oct 31 – Nov 7, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,270
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Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Nov 7 – Nov 14, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,069
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Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 10 nights Nov 14 – Nov 24, 2026 from Colon, Panama
Colon, Panama · Kralendijk, Bonaire, Dutch Antilles · … · Colon, Panama7 ports
Colon, Panama · Kralendijk, Bonaire, Dutch Antilles · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Port of Spain, Trinidad · Scarborough, Tobago · Colon, Panama
★ Bucket-list Panama Canal Full TransitKlein BonaireArubaPrivate Full-Day Curaçao Island Tour with Local Ex… +2 more
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from $1,542
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Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Dec 19, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Kralendijk, Bonaire, Dutch Antilles · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaKlein Bonaire
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from $1,675
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Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Dec 26, 2026 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $2,477
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Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Jan 2 – Jan 9, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,267
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Windstar · Wind StarOne-way
Pacific 7 nights Jan 2 – Jan 9, 2027 from Colon, Panama to Puerto Caldera, Costa Rica
Colon, Panama · Balboa, Panama · … · Puerto Caldera, Costa Rica8 ports
Colon, Panama · Balboa, Panama · Panama Canal, Panama · Balboa, Panama · Isla Parida, Panama · Puerto Jimenez, Costa Rica · Quepos, Costa Rica · Puerto Caldera, Costa Rica
★ Bucket-list Panama Canal Full TransitPanama Canal Partial TransitPanama Canal Full TransitCorcovado's Sirena Station +2 more
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from $4,850
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Windstar · Star LegendOne-way
Pacific 7 nights Jan 5 – Jan 12, 2027 from Colon, Panama to Puerto Caldera, Costa Rica
Colon, Panama · Balboa, Panama · … · Puerto Caldera, Costa Rica8 ports
Colon, Panama · Balboa, Panama · Panama Canal, Panama · Balboa, Panama · Isla Parida, Panama · Puerto Jimenez, Costa Rica · Quepos, Costa Rica · Puerto Caldera, Costa Rica
★ Bucket-list Panama Canal Full TransitPanama Canal Partial TransitPanama Canal Full TransitCorcovado's Sirena Station +2 more
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from $3,718
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Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Jan 9 – Jan 16, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,267
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Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Jan 16 – Jan 23, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Willemstad, Curacao · Port of Oranjestad, Aruba, Caribbean · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…Private Full-Day Curaçao Island Tour with Local Ex…Aruba
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from $1,587
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Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Jan 23 – Jan 30, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · … · Colon, Panama6 ports
Colon, Panama · Cartagena, Colombia · Kralendijk, Bonaire, Dutch Antilles · Willemstad, Curacao · Port of Oranjestad, Aruba, Caribbean · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…Klein BonairePrivate Full-Day Curaçao Island Tour with Local Ex… +1 more
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from $1,218
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Jan 30 – Feb 6, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · … · Colon, Panama6 ports
Colon, Panama · Cartagena, Colombia · Willemstad, Curacao · Port of Oranjestad, Aruba, Caribbean · Kralendijk, Bonaire, Dutch Antilles · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…Private Full-Day Curaçao Island Tour with Local Ex…Aruba +1 more
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from $1,167
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Feb 6 – Feb 13, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
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from $1,356
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Feb 13 – Feb 20, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Kralendijk, Bonaire, Dutch Antilles · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaKlein Bonaire
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from $1,051
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Feb 20 – Feb 27, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,157
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Feb 27 – Mar 6, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,287
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Mar 6 – Mar 13, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,127
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Mar 13 – Mar 20, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · … · Colon, Panama6 ports
Colon, Panama · Cartagena, Colombia · Willemstad, Curacao · Kralendijk, Bonaire, Dutch Antilles · Port of Oranjestad, Aruba, Caribbean · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…Private Full-Day Curaçao Island Tour with Local Ex…Klein Bonaire +1 more
View →
from $1,295
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Mar 20 – Mar 27, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,154
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Mar 27 – Apr 3, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · … · Colon, Panama6 ports
Colon, Panama · Cartagena, Colombia · Willemstad, Curacao · Kralendijk, Bonaire, Dutch Antilles · Port of Oranjestad, Aruba, Caribbean · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…Private Full-Day Curaçao Island Tour with Local Ex…Klein Bonaire +1 more
View →
from $1,262
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Apr 3 – Apr 10, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,234
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Apr 10 – Apr 17, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · … · Colon, Panama6 ports
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Kralendijk, Bonaire, Dutch Antilles · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaKlein Bonaire +1 more
View →
from $1,308
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Apr 17 – Apr 24, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,306
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasOne-way
Caribbean 7 nights Apr 24 – May 1, 2027 from Colon, Panama to San Juan, Puerto Rico
Colon, Panama · Port of Kingstown, St. Vincent & the Grenadines · … · San Juan, Puerto Rico6 ports
Colon, Panama · Port of Kingstown, St. Vincent & the Grenadines · Castries, St. Lucia · St. John's, Antigua · Tortola, B.V.I. · San Juan, Puerto Rico
★ Bucket-list Panama Canal Full TransitLa Soufrière Volcano Summit HikeCosol ToursPrivate Half-Day Island Adventure & Trunk Bay Beach +2 more
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from $472
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Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Dec 4 – Dec 11, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,118
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Dec 11 – Dec 18, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $966
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Caribbean 7 nights Dec 18 – Dec 25, 2027 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Willemstad, Curacao · Port of Oranjestad, Aruba, Caribbean · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…Private Full-Day Curaçao Island Tour with Local Ex…Aruba
View →
from $1,018
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Dec 25 – Jan 1, 2028 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,077
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Jan 1 – Jan 8, 2028 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Willemstad, Curacao · Port of Oranjestad, Aruba, Caribbean · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…Private Full-Day Curaçao Island Tour with Local Ex…Aruba
View →
from $1,119
Book This Cruise@ Cruisebound
Royal Caribbean · Grandeur of the SeasRound-trip
Panama Canal 7 nights Jan 8 – Jan 15, 2028 from Colon, Panama
Colon, Panama · Cartagena, Colombia · Port of Oranjestad, Aruba, Caribbean · Willemstad, Curacao · Colon, Panama
★ Bucket-list Panama Canal Full TransitThe Roman Theatre of Cartagena with the Rafael Mon…ArubaPrivate Full-Day Curaçao Island Tour with Local Ex…
View →
from $1,104
Book This Cruise@ Cruisebound
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Itineraries from the Cruisebound catalog + our enrichment; schedules cross-checked against official port authorities. Booking via Cruisebound and CruiseDirect — we may earn a commission, at no extra cost to you.

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MSC Cruises Royal Caribbean Carnival Viking River Norwegian AmaWaterways Costa Princess Celebrity Avalon Disney Viking Ocean Holland America Silversea Oceania Virgin Regent Explora Journeys Cunard Azamara Windstar Seabourn Virgin Voyages